VITAMIN D INTOXICATION IN INFANTS WITH VITAMIN D SUPPLEMENTS

Authors

  • Awat J. Mustafa Sulaimani Pediatrics Teaching Hospital, Kurdistan Region, Iraq.
  • Aso F. Salih Department of Pediatrics, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.17656/jsmc.10241

Keywords:

Infants Pediatrics, Vitamin D intoxication, Vitamin D supplement, Sulaimani

Abstract

Background 

Vitamin D supplementation can lead to a rare condition of vitamin D intoxication in infants develop. Thus, its supplementation had to raise concerns because the frequency of its intoxication is increasing. 

Objectives 

The aim was to look for frequencies of vitamin D intoxication among infants who had vitamin D supplements in Sulaimani City.

Patients and Methods

A cross-sectional study performed on 65 infants for a period of a month from February 1st to March 1st, 2019. Inclusion criteria were infants with vitamin D supplements for at least six consecutive months and aged between eight months to two years old. The ages and gender of the infants, as well as the level of vitamin D, and the daily amount and route of vitamin D supplements, were recorded. The “IBM SPSS Statistics version 25” was used for the analysis of the data, and a P-value of (≤0.05) was considered significant.

Results

The mean±SD of age was 1.26±0.52 years (range; 8 months to 2 years), and the genders were male (29.2%) and female (70.8%) with a female to male ratio of (2.4:1). Mean±SD vitamin of D3 level (ng/mL) was 37.97 ± 14.64 (range; 6.76 to 78). There were insignificant associations between the levels of vitamin D3 with age, gender of the infants, daily supplement and the route of vitamin supplementation. No infants were found to have vitamin D intoxication. 

Conclusion

No infants had vitamin D intoxication, although they were provided with vitamin D supplements.

References

- Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press, 2010.

- Radlović N, Leković Z, Ristić D, Radlović V, Djuričić G, Dimitrijević A, et al. Case Report of Acute Vitamin D Intoxication in an Infant. Srp Arh Celok Lek. 2014; 142(11-12):736-9. DOI: https://doi.org/10.2298/SARH1412736R

- Demir K, Döneray H, Kara C, Atay Z, Çetinkaya S, Çayır A, et al. Comparison of Treatment Regimens for the Management of Severe Hypercalcemia due to Vitamin D Intoxication in Children. J Clin Res Pediatr Endocrinol. 2018. doi: 10.4274/jcrpe.0131. DOI: https://doi.org/10.4274/jcrpe.0131

- Kara C, Çetinkaya S, Gündüz S, Can Yılmaz G, Aycan Z, Aydın M. Efficacy and safety of pamidronate in children with vitamin D intoxication. Pediatr Int. 2016; 58(7):562-8. DOI: https://doi.org/10.1111/ped.12875

- Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity–A Clinical Perspective. Front Endocrinol (Lausanne). 2018; 9:550. DOI: https://doi.org/10.3389/fendo.2018.00550

- Pérez-Barrios C, Hernández-Álvarez E, Blanco-Navarro I, Pérez-Sacristán B, Granado-Lorencio F. Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. Clin Nutr. 2016; 35(6):1354-8. DOI: https://doi.org/10.1016/j.clnu.2016.02.017

- Talarico V, Barreca M, Galiano R, Galati MC, Raiola G. Vitamin D and Risk for Vitamin A Intoxication in an 18-Month-Old Boy. Case Rep Pediatr. 2016; 2016:1395718. DOI: https://doi.org/10.1155/2016/1395718

- Sagsak E, Savas-Erdeve S, Keskin M, Cetinkaya S, Aycan Z. The use of pamidronate for acute vitamin D intoxication, clinical experience with three cases. J Pediatr Endocrinol Metab. 2015; 28(5-6):709-12. DOI: https://doi.org/10.1515/jpem-2014-0279

- Bilbao NA. Vitamin D Toxicity in Young Breastfed Infants: Report of 2 Cases. Glob Pediatr Health. 2017; 4: 2333794X17731695. DOI: https://doi.org/10.1177/2333794X17731695

- Marins TA, Galvão Tde F, Korkes F, Malerbi DA, Ganc AJ, Korn D, et al. Vitamin D intoxication: case report. Einstein (Sao Paulo). 2014; 12(2):242-4. DOI: https://doi.org/10.1590/S1679-45082014RC2860

Published

2020-03-21

How to Cite

1.
Mustafa A, Salih A. VITAMIN D INTOXICATION IN INFANTS WITH VITAMIN D SUPPLEMENTS. JSMC [Internet]. 2020 Mar. 21 [cited 2024 Jul. 4];10(1):67-71. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10241

Similar Articles

1-10 of 421

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)