EVALUATION OF VITAMIN D IN MOTHERS AND NEWBORNS AT BIRTH IN SULAIMANI MATERNITY TEACHING HOSPITAL
DOI:
https://doi.org/10.17656/jsmc.10409Keywords:
Vitamin D, Pregnancy, Vitamin D deficiency, Birth weight, Preterm birth, Apgar scoreAbstract
Background
Deficiencies in vitamin D are frequent worldwide. Approximately 1 billion individuals around the globe are vitamin D deficient (<20ng/ml), and half of the population is insufficient (20-29ng/ml). According to extensive epidemiological studies, vitamin D deficiency is common in women, particularly pregnant and nursing mothers. Vitamin D deficiency during pregnancy is associated with various maternal and fetal health effects.
Objectives
Vitamin D levels in fetuses and newborns are directly related to their mothers’ levels during pregnancy. The study aims to assess and compare the vitamin D levels of mothers and their newborn babies. Additionally, we are interested in determining whether there is a link between vitamin D levels and delivery outcomes.
Patients and Methods
One hundred pairs of mothers and newborns enrolled in a cross-sectional study at Maternity Teaching Hospital in Sulaimani. Any newborn baby diagnosed with a congenital abnormality during pregnancy was excluded. Also, any mother that was on anticonvulsant drugs was excluded. Blood samples for vitamin D analysis were taken from the mothers and newborns at birth. In addition, the demographic and medical data of the mothers and newborns were recorded. All evaluations had a p-value of 0.05 as the threshold for statistical significance.
Results
The mothers’ and newborns’ mean vitamin D were 17.2±13.33 ng/ml and 10.48±9.77 ng/ml, respectively. An examination of the data using statistical methods indicated a connection between the vitamin D found in mothers and the levels found in their newborns (p-value=0.001). Furthermore, higher levels during pregnancy were linked to better Apgar scores (≥7) for their newborn children (p-value=0.03). Maternal vitamin D level was not statistically associated with other birth outcomes; p-value > 0.05.
Conclusion
The results of this study show that vitamin D deficiency in mothers leads to deficiency in their newborns. Except for the Apgar score, no statistically significant relationship was found between maternal vitamin D levels and other birth outcomes.
References
Kim MJ, Na B, No SJ, Han HS, Jeong EH, Lee W, et al. Nutritional status of vitamin D and the effect of vitamin D supplementation in Korean breast-feed infants. Journal of Korean medical science. 2010;25(1):83-9. DOI: https://doi.org/10.3346/jkms.2010.25.1.83
Lo T-H, Wu T-Y, Li P-C, Ding D-C. Effect of Vitamin D supplementation during pregnancy on maternal and perinatal outcomes. Ci Ji Yi Xue Za Zhi. 2019;31(4):201-6. DOI: https://doi.org/10.4103/tcmj.tcmj_32_19
Mithal A, Kalra S. Vitamin D supplementation in pregnancy. Indian J Endocrinol Metab. 2014;18(5):593-6. DOI: https://doi.org/10.4103/2230-8210.139204
Bhimji KM, Naburi H, Aboud S, Manji K. Vitamin D Status and Associated Factors in Neonates in a Resource Constrained Setting. International Journal of Pediatrics. 2018;2018:9614975. DOI: https://doi.org/10.1155/2018/9614975
Kiely M, Hemmingway A, O'Callaghan KM. Vitamin D in pregnancy: current perspectives and future directions. Ther Adv Musculoskelet Dis. 2017;9(6):145-54. DOI: https://doi.org/10.1177/1759720X17706453
Curtis EM, Moon RJ, Harvey NC, Cooper C. Maternal vitamin D supplementation during pregnancy. British medical bulletin. 2018;126(1):57-77. DOI: https://doi.org/10.1093/bmb/ldy010
Urrutia-Pereira M, Solé D. [Vitamin D deficiency in pregnancy and its impact on the fetus, the newborn and in childhood]. Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo. 2015;33(1):104-13. DOI: https://doi.org/10.1016/S2359-3482(15)30036-1
Shor DB, Barzel J, Tauber E, Amital H. The effects of maternal vitamin D on neonatal growth parameters. European journal of paediatrics. 2015;174(9):1169-74. DOI: https://doi.org/10.1007/s00431-015-2517-5
Dawodu A, Tsang RC. Maternal vitamin D status affects breast-feeding infants' milk vitamin D content and vitamin D status. Advances in nutrition (Bethesda, Md). 2012;3(3):353-61. DOI: https://doi.org/10.3945/an.111.000950
Fink C, Peters RL, Koplin JJ, Brown J, Allen KJ. Factors Affecting Vitamin D Status in Infants. Children (Basel). 2019;6(1):7. DOI: https://doi.org/10.3390/children6010007
Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circulation research. 2019;124(7):1094-112. DOI: https://doi.org/10.1161/CIRCRESAHA.118.313276
Fogacci S, Fogacci F, Banach M, Michos ED, Hernandez AV, Lip GYH, et al. Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials. Clinical nutrition (Edinburgh, Scotland). 2020;39(6):1742-52. DOI: https://doi.org/10.1016/j.clnu.2019.08.015
Khalessi N, Kalani M, Araghi M, Farahani Z. The Relationship between Maternal Vitamin D Deficiency and Low Birth Weight Neonates. Journal of Family & reproductive health. 2015;9(3):113-7.
Moukarzel S, Ozias M, Kerling E, Christifano D, Wick J, Colombo J, et al. Maternal Vitamin D Status and Infant Infection. Nutrients. 2018;10(2). DOI: https://doi.org/10.3390/nu10020111
Chauhan K, Shahrokhi M, Huecker MR. Vitamin D.StatPearls. Treasure Island (FL): StatPearls Publishing,Copyright © 2022, StatPearls Publishing LLC.; 2022.
Esmeraldo CUP, Martins MEP, Maia ER, Leite JLA, Ramos JLS, Gonçalves J, Jr., et al. Vitamin D in Term Newborns: Relation with Maternal Concentrations and Birth Weight. Annals of nutrition & metabolism. 2019;75(1):39-46. DOI: https://doi.org/10.1159/000502044
Elechi HA, Oduwole A, Idris HW, Faruk MB, Alhaji MA. Vitamin D and bone mineral status of newborn-maternal pair delivering at a tertiary hospital in Nigeria. Nigerian journal of clinical practice. 2021;24(3):345-54. DOI: https://doi.org/10.4103/njcp.njcp_368_20
Wang Y, Li H, Zheng M, Wu Y, Zeng T, Fu J, et al. Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study. PloS one. 2018;13(4):e0195700. DOI: https://doi.org/10.1371/journal.pone.0195700
Özdemir AA, Ercan Gündemir Y, Küçük M, Yıldıran Sarıcı D, Elgörmüş Y, Çağ Y, et al. Vitamin D Deficiency in Pregnant Women and Their Infants. Journal of clinical research in pediatric endocrinology. 2018;10(1):44-50. DOI: https://doi.org/10.4274/jcrpe.4706
Fedakâr A. Vitamin D Deficiency, Prevalence and Treatment in Neonatal Period. Endocrine, metabolic & immune disorders drug targets. 2019;19(6):866-73. DOI: https://doi.org/10.2174/1871530319666190215152045
Weinert LS, Silveiro SP. Maternal-fetal impact of vitamin D deficiency: a critical review. Maternal and child health journal. 2015;19(1):94-101. DOI: https://doi.org/10.1007/s10995-014-1499-7
Lian RH, Qi PA, Yuan T, Yan PJ, Qiu WW, Wei Y, et al. Systematic review and meta-analysis of vitamin D deficiency in different pregnancies on preterm birth: Deficiency in middle pregnancy might be at risk. Medicine. 2021;100(24):e26303. DOI: https://doi.org/10.1097/MD.0000000000026303
Almidani E, Barkoumi A, Elsaidawi W, Al Aliyan S, Kattan A, Alhazzani F, et al. Maternal Vitamin D Levels and Its Correlation With Low Birth Weight in Neonates: A Tertiary Care Hospital Experience in Saudi Arabia. Cureus. 2021;13(4):e14528. DOI: https://doi.org/10.7759/cureus.14528
Eggemoen Å R, Jenum AK, Mdala I, Knutsen KV, Lagerløv P, Sletner L. Vitamin D levels during pregnancy and associations with birth weight and body composition the newborn: a longitudinal multiethnic population-based study. The British journal of nutrition. 2017;117(7):985-93. DOI: https://doi.org/10.1017/S000711451700068X
Miliku K, Vinkhuyzen A, Blanken LM, McGrath JJ, Eyles DW, Burne TH, et al. Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. The American journal of clinical nutrition. 2016;103(6):1514-22. DOI: https://doi.org/10.3945/ajcn.115.123752
Chen YH, Fu L, Hao JH, Yu Z, Zhu P, Wang H, et al. Maternal vitamin D deficiency during pregnancy elevates the risks of early gestational age and low birth weight infants in the Chinese population. The journal of clinical endocrinology and metabolism. 2015;100(5):1912-9. DOI: https://doi.org/10.1210/jc.2014-4407
Chen GD, Pang TT, Li PS, Zhou ZX, Lin DX, Fan DZ, et al. Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study. BMC pregnancy and childbirth. 2020;20(1):465. DOI: https://doi.org/10.1186/s12884-020-03158-6
Lee SS, Ling KH, Tusimin M, Subramaniam R, Rahim KF, Loh SP. Interplay between Maternal and Neonatal Vitamin D Deficiency and Vitamin-D-Related Gene Polymorphism with Neonatal Birth Anthropometry. Nutrients. 2022;14(3). DOI: https://doi.org/10.3390/nu14030564
Kim I, Kim SS, Song JI, Yoon SH, Park GY, Lee Y-W. Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants. Korean J Pediatr. 2019;62(5):166-72. DOI: https://doi.org/10.3345/kjp.2018.06632
Boskabadi H, Mamoori G, Khatami SF, Faramarzi R. Serum vitamin D level in preterm infants and its association with premature-related respiratory complications: a case-control study. Electron Physician. 2018;10(1):6208-14. DOI: https://doi.org/10.19082/6208
Augustin H, Mulcahy S, Schoenmakers I, Bullarbo M, Glantz A, Winkvist A, et al. Late Pregnancy, Vitamin D Deficiency, is Associated with Doubled Odds of Birth Asphyxia and Emergency Caesarean Section: A Prospective Cohort Study. Maternal and child health journal. 2020;24(11):1412-8. DOI: https://doi.org/10.1007/s10995-020-02999-z
Hossain N, Kanani FH, Ramzan S, Kausar R, Ayaz S, Khanani R, et al. Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in Pakistani women. The journal of clinical endocrinology and metabolism. 2014;99(7):2448-55. DOI: https://doi.org/10.1210/jc.2013-3491
Dogan P, Ozkan H, Koksal N, Bagci O, Varal IG. Vitamin D deficiency and its effect on respiratory distress syndrome in premature infants: results from a prospective study in a tertiary care centre. Afr Health Sci. 2020;20(1):437-43. DOI: https://doi.org/10.4314/ahs.v20i1.50
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