EVALUATION OF SERUM CA-125 LEVEL IN NORMAL AND PRE-ECLAMPTIC PREGNANCIES IN SULAIMANI CITY
DOI:
https://doi.org/10.17656/jsmc.10277Keywords:
Pre-eclampsia, CA 125 level, Severe pre-eclampsiaAbstract
Background
Pre-eclampsia is a hypertensive disorder of pregnancy which may cause morbidity and even mortality for both the mother and the fetus. Blood pressure elevation is the most visible sign of pre-eclampsia; however, the disease is multi-systemic affecting almost all systems of the body. CA125 has been found to be elevated in normal and pre-eclamptic pregnancies.
Objectives
To assess the level of CA-125 in normal and pre-eclamptic pregnancies to find out whether this marker is significantly elevated in women with pre-eclampsia, also to find out any correlation between the severity of pre-eclampsia and the serum concentration of CA 125.
Patients and Methods
This was a case control study, carried out in Sulaimani Maternity teaching hospital over a period of one year starting from the 1st of May 2015 to the 30th of April 2016. The study included 150 pregnant women, with singleton pregnancy in their 3rd trimester, these women were categorized into three group, fifty women with healthy pregnancy (the control group). Fifty women with mild pre-eclampsia and fifty women with severe pre-eclampsia (the study groups). The serum CA125 level was measured for the women in the three groups and comparison was made among them.
Results
Mean serum CA-125 and mean arterial pressure were significantly higher in the pre-eclamptic groups compared to the control group (P- value =0.0001). There was a direct correlation between CA-125 and mean arterial pressure in pregnant women with severe pre-eclampsia. The sensitivity and specificity of CA- 125 level were 94% for the detection of pre-eclamptic pregnancies.
Conclusion
Serum CA-125 was significantly higher in pre-eclampsia groups in comparison to the control group and the level was directly correlated with the severity of pre-eclampsia.
References
Cunningham FG, Leveno JK, Bloom SL. Pregnancy hypertension. In: Williams Obstetrics. 23rd ed. McGraw-Hill Company (publisher) ;2010. P. 706-756.
Castro LC. Hypertensive disorder of pregnancy. In: Hacker N F, Janbone J C, Hobel C J editors. Essential of Obstetrics and Gynaecology. 5th ed. Elsevier (publishers); 2010. P. 173-182. DOI: https://doi.org/10.1016/B978-1-4160-5940-0.00014-X
Sibia B. Hypertension. In: Drife J, Magowan O editors. Clinical Obstetrics and Gynecology 2nd ed. Human press; 2008. P. 367-370.
Louise C. Kenny. Pre-eclampsia and other disorder of placentation. In: Philip N. Baker and Louise C. Kenny editors. Obstetrics by ten teachers. 19th ed. Edward Arnold (publishers);2011. p.120-125.
Jason J.S. Waughand Maria C. Smith. Hypertensive disorders. In: Edmonds D editors. Dewhurst’s Textbook of Obstetrics & Gynaecology. 8th ed. Blackwell publishing; 2012. p. 101-185.
Andrew Shennan. Pre-eclampsia and non proteinuric pregnancy-induced hypertension. In: David M. Luesley, Philip N. Baker editors. Obstetrics and Gynaecology, An evidence-based text for MRCOG. 2nd ed. Edward Arnold (publishers); 2010. p. 184-191.
Marciano D. Hypertension in Pregnancy. In: Pfeifer S editors. Obstetrics &Gynecology 7th ed. Lippincott Williams &Wilkins (publishers); 2012. P. 168-173
Center for Maternal and Child Enquiries. Saving Mothers Lives: Reviewing Maternal Deaths to make motherhood Safer: 2006-2008. The Eighth Report on Confidential Enquiries into maternal deaths in the United Kingdom. BJOG 2011; 118 ( Suppl 1):1-203. DOI: https://doi.org/10.1111/j.1471-0528.2010.02847.x
Verlohren S, Herraiz I, Lapaire O: The sFLt-PlGF ratio in different types of hypertensive pregnancy disorders and prognostic potential in pre-eclamptic patients. Am J Obstet Gynecol.2012; 206: 58-68. DOI: https://doi.org/10.1016/j.ajog.2011.07.037
Eruo F, Sibai B. Hypertensive Disease in Pregnancy. In: Reece E, Hobbins J editors. Clinical Obstetrics the Fetus & The Mother.3rd ed. Blackwell publishing; 2007. p. 683-699. DOI: https://doi.org/10.1002/9780470753293.ch38
Lindheimer MD, Taler S, and Cunningham FG: Hypertensive disorders in Pregnancy J Am Soc Hyper (2009), 6:484. DOI: https://doi.org/10.1016/j.jash.2008.10.001
Alexander J, Andujo O, Leveno K. Gestational hypertension and pre-eclampsia. Williams’s manual of pregnancy complications.23rd ed. McGraw-Hill publisher; 2013. p. 171-187.
Fridman SA, lindheimer MD. Prediction and differential diagnosis. In: Lindheimer MD, Robert JM, Cunninham FG editors. Hypertensive disorders in pregnancy.2nd ed. Stamford, CT, Appleton and Lange (publishers); 1999. p. 201.
Cebesoy FB, Balat O and Dikensoy E, Kalayci H and Ibar Y: CA-125 and CRP are Elevated in pre-eclampsia. In: Hypertension in pregnancy.2009; 28:201–11. DOI: https://doi.org/10.1080/10641950802601187
Ozat M, Pektas MK and Yenicesu O: Serum concentrations of CA-125 in normal and preeclamptic pregnancies. In: Archives of Gynecology and Obstetrics, 2010:1-9. DOI: https://doi.org/10.1007/s00404-010-1736-2
Lindheimer MD, Taler AJ, Cunningham FG, Hypertension in Pregnancy. J Am Soc Hypertens.2010; 4(2):68-78. DOI: https://doi.org/10.1016/j.jash.2010.03.002
Seow KM, Tang MH, Chuang J, Wang Y, and Chen D: The Correlation Between Renal Function and Systolic or Diastolic Blood Pressure in severe pre-eclamptic Women. In: Hypertension in Pregnancy, 2005; 24:247–57. DOI: https://doi.org/10.1080/10641950500281126
Pacarizi H, Begolli L, Lulaj S and Gafurri Z, Blood urea nitrogen/ Creatinine index is a predictor of pre-renal damage in pre-eclampsia of Health Sciences; 2012, 2(1):61-65. DOI: https://doi.org/10.17532/jhsci.2012.65
Manjareeka M, Nanda S. Elevated levels of serum uric acid, creatinine or Urea in pre-eclamptic women. Int J Med Sci Public Health. 2013; 2:43-47. DOI: https://doi.org/10.5455/ijmsph.2013.2.43-47
Bon GG, Kenemans P and Verstraeten AA. Maternal serum CA-125 and CA-15-3 antigen levels in normal and pathological pregnancy. In: Fetal Diagn Therpy. 2001; 16(3):166-72. DOI: https://doi.org/10.1159/000053903
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