UPPER GASTROINTESTINAL ENDOSCOPIC FINDINGS AND HELICOBACTER PYLORI INFECTION: DIABETIC VERSUS NON-DIABETIC DYSPEPTIC PATIENTS IN SULAIMANI CITY
DOI:
https://doi.org/10.17656/jsmc.10171Keywords:
Diabetes, H. pylori, EndoscopyAbstract
Background
Diabetes Mellitus is a chronic lifelong condition that widely affects whole body systems. The gastrointestinal tract is one of these systems that is significantly affected by diabetes mellitus. Infection is common and is sometimes severe among diabetic patients.
Objectives
To determine the association between H. pylori infection and diabetes mellitus and to show any difference in upper GI endoscopic findings between diabetic and non-diabetic patients who presented with dyspepsia.
Methods
This study is a retrospective study. Sixty diabetic and 60 non-diabetic patients were enrolled in this study, all presented with dyspeptic symptoms, underwent upper GI endoscopy. H. pylori status was evaluated. Glycemic control of diabetic patients was assessed by HbA1c. Comparison between diabetic and non-diabetic patients done.
Results
The prevalence of H. pylori infection was 81.66% among diabetic patients, and 68.33% among nondiabetic patients and the difference in the occurrence of H. pylori between those 2 groups statistically not significant. The duration of diabetes and level of HbA1c were not related to the prevalence of H. pylori infection. The upper GI endoscopic findings were not significantly different between those two groups.
Conclusion
Our study does reveal that although H. pylori infection is more common among diabetics than nondiabetic patients such difference was not statistically significant. There was no significant difference in upper GI endoscopic findings between diabetic and non-diabetic groups.
References
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26 Suppl 1: S5-20. DOI: https://doi.org/10.2337/diacare.26.2007.S5
Goff DC, Gerstein HC, Ginsberg HN, et al. Prevention of cardiovascular disease in persons with type 2 diabetes mellitus: current knowledge and rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol 2007; 99: 4i–20i. DOI: https://doi.org/10.1016/j.amjcard.2007.03.002
Genuth S, Alberti KGMM, Bennett P, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003; 26: 3160–3167. DOI: https://doi.org/10.2337/diacare.26.11.3160
Feldman M, Schiller LR. Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 1983; 98: 378–384. DOI: https://doi.org/10.7326/0003-4819-98-3-378
Farup CE, Leidy NK, Murray M, et al. Effect of domperidone on the health-related quality of life of patients with symptoms of diabetic gastroparesis. Diabetes Care 1998; 21: 1699–1706. DOI: https://doi.org/10.2337/diacare.21.10.1699
Verne GN, Sninsky CA. Diabetes and the gastrointestinal tract. Gastroenterol Clin North Am 1998; 27: 861–874, vi–vii. DOI: https://doi.org/10.1016/S0889-8553(05)70035-2
Koch KL. Diabetic gastropathy: gastric neuromuscular dysfunction in diabetes mellitus: a review of symptoms, pathophysiology, and treatment. Dig Dis Sci 1999; 44: 1061–1075. DOI: https://doi.org/10.1023/A:1026647417465
Samsom M, Smout AJ. Abnormal gastric and small intestinal motor function in diabetes mellitus. Dig Dis Basel Switz 1997; 15: 263–274. DOI: https://doi.org/10.1159/000171603
Rothstein RD. Gastrointestinal motility disorders in diabetes mellitus. Am J Gastroenterol 1990; 85: 782–785.
Scarpello JH, Sladen GE. Diabetes and the gut. Gut 1978; 19: 1153–1162. DOI: https://doi.org/10.1136/gut.19.12.1153
Mégraud F. Epidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am 1993; 22: 73–88. DOI: https://doi.org/10.1016/S0889-8553(21)00264-8
Buta N, Tanih N, Ndip R. Increasing trend of metronidazole resistance in the treatment of Helicobacter pylori infection: A global challenge. Afr J Biotechnol 2010; 9: 1115–1121. DOI: https://doi.org/10.5897/AJB2010.000-3015
Oldenburg B, Diepersloot RJ, Hoekstra JB. High seroprevalence of Helicobacter pylori in diabetes mellitus patients. Dig Dis Sci 1996; 41: 458–461. DOI: https://doi.org/10.1007/BF02282318
Perdichizzi G, Bottari M, Pallio S, et al. Gastric infection by Helicobacter pylori and antral gastritis in hyperglycemic obese and in diabetic subjects. New Microbiol 1996; 19: 149–154.
Kojecký V, Roubalík J, Bartoníková N. [Helicobacter pylori in patients with diabetes mellitus]. Vnitr Lek 1993; 39: 581–584.
Williams textbook of endocrinology . - NLM Catalog- NCBI, Available on https://www.ncbi.nlm. nih .gov / nlmcatalog /9010985 (accessed 22 January 2018).
Papamichael KX, Papaioannou G, Karga H, et al. Helicobacter pylori infection and endocrine disorders: is there a link? World J Gastroenterol 2009; 15: 2701–2707. DOI: https://doi.org/10.3748/wjg.15.2701
Gulcelik NE, Kaya E, Demirbas B, et al. Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy. J Endocrinol Invest 2005; 28: 214–217. DOI: https://doi.org/10.1007/BF03345375
Woodward M, Morrison C, McColl K. An investigation into factors associated with Helicobacter pylori infection. J Clin Epidemiol 2000; 53: 175–181. DOI: https://doi.org/10.1016/S0895-4356(99)00171-7
Rosenstock SJ, Jørgensen T, Andersen LP, et al. Association of Helicobacter pylori infection with lifestyle, chronic disease, body-indices, and age at menarche in Danish adults. Scand J Public Health 2000; 28: 32–40. DOI: https://doi.org/10.1177/140349480002800107
Xia HH, Talley NJ, Kam EP, et al. Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus. Am J Gastroenterol 2001; 96: 1039–1046. DOI: https://doi.org/10.1111/j.1572-0241.2001.03604.x
Ko GT, Chan FK, Chan WB, et al. Helicobacter pylori infection in Chinese subjects with type 2 diabetes. Endocr Res 2001; 27: 171–177. DOI: https://doi.org/10.1081/ERC-100107178
Ojetti V, Pitocco D, Ghirlanda G, et al. [Role of Helicobacter pylori infection in insulin-dependent diabetes mellitus]. Minerva Med 2001; 92: 137–144.
Clyne M, Labigne A, Drumm B. Helicobacter pylori requires an acidic environment to survive in the presence of urea. Infect Immun 1995; 63: 1669–1673. DOI: https://doi.org/10.1128/iai.63.5.1669-1673.1995
Downloads
Published
Issue
Section
License
Copyright (c) 2018 Mohammad Shekhani and Shaho F. Ahmad
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This work is licensed under 