STATE OF THYROID GLAND FUNCTION IN PATIENTS ADMITTED TO CORONARY CARE UNIT

Authors

  • Amanj Abubakr Jalal Khaznadar College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Zaynab Muhammed Bahadir Baban Internal Medicine Board Trainee, Ministry of Health, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.17656/jsmc.10394

Keywords:

Thyroid gland, TFT abnormalities, CCU

Abstract

Background 

A large number of patients are admitted to coronary care units daily. Thyroid gland abnormalities are one of the reasons which cause people to have cardiac events. Therefore, detecting thyroid gland abnormalities among cardiac care unit patients and early management leads to less morbidity/mortality and a better long-term prognosis for those patients.

Objectives 

The study was done to detect the function of thyroid gland abnormalities and their effect on different cardiac conditions among patients admitted to CCU.

Patients Methods

This descriptive cross-sectional study includes a consecutive non-random sampling of 201 patients. All the patients enrolled in this study were admitted to the CCU unit of Sulaimanya Teaching Hospital and Shar Hospital in Sulaimanya city/Iraq between August 2021 and January 2022. Thyroid function test and lipid profile were checked for the participants. The pediatric age group, pregnant women, patients with malignancies/ severe systemic illness /on amiodarone/ congenital heart disease were excluded. Statistical Package analysed the collected data for Social Science (SPSS) (version 22.0).

Results

One hundred fifteen (57.2%) participants were male, and 86(42.8%) were female. The most common age group was between 45-64 years. HTN(%44.3), diabetes (29.9%) and hyperlipidemia (17.9%) were common comorbid conditions. The most common cause of admissions to CCU was due to ACS (63.2%) and then arrhythmia (22.9%), decompensated heart failure (12.9%) and pericardial diseases (1%). In addition, 82.59% (166) of the participants were euthyroid, and 17.41% (35) had thyroid gland function abnormalities.

Conclusion 

The effect of thyroid hormone problems on cardiac conditions is one of the important causes of CCU admissions. Patients with ACS and heart failure are presented with hypothyroidism. However, arrhythmia is present more in cases of hyperthyroidism.

References

Grais IM, Sowers JR. Thyroid and the heart. Am J Med. 2014;127(8):691-8. DOI: https://doi.org/10.1016/j.amjmed.2014.03.009

Vargas-Uricoechea H, Bonelo-Perdomo A, Sierra-Torres CH. Effects of thyroid hormones on the heart. Clin Investig Arterioscler. 2014;26(6):296-309. DOI: https://doi.org/10.1016/j.arteri.2014.07.003

Ling Y, Jiang J, Gui M, Liu L, Aleteng Q, Wu B, et al. Thyroid Function, Prevalent Coronary Heart Disease, and Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography. Int J Endocrinol. 2015;2015: 708272. DOI: https://doi.org/10.1155/2015/708272

Vale C, Neves JS, von Hafe M, Borges-Canha M, Leite-Moreira A. The Role of Thyroid Hormones in Heart Failure. Cardiovasc Drugs Ther. 2019;33(2):179-88. DOI: https://doi.org/10.1007/s10557-019-06870-4

Ciavardelli D, Bellomo M, Crescimanno C, Vella V. Type 3 deiodinase: role in cancer growth, stemness, and metabolism. Front Endocrinol (Lausanne). 2014;5:215. DOI: https://doi.org/10.3389/fendo.2014.00215

Klein I, Danzi S. Thyroid Disease and the Heart. Curr Probl Cardiol. 2016; 41(2):65–92. DOI: https://doi.org/10.1016/j.cpcardiol.2015.04.002

Razvi S, Jabbar A, Pingitore A, Danzi S, Biondi B, Klein I, et al. Thyroid Hormones and Cardiovascular Function and Diseases. J Am Coll Cardiol. 2018;71(16):1781-96. DOI: https://doi.org/10.1016/j.jacc.2018.02.045

Hernando VU. Role of Thyroid Hormones in Different Aspects of Cardiovascular System. Endocrinol Metab Syndr. 2015; 4(2). DOI: https://doi.org/10.4172/2161-1017.1000166

Janssen R, Muller A, Simonides WS. Cardiac Thyroid Hormone Metabolism and Heart Failure. Eur Thyroid J. 2017; 6(3):130–7. DOI: https://doi.org/10.1159/000469708

Reddy V, Taha W, Kundumadam S, Khan M. Atrial fibrillation and hyperthyroidism: A literature review. Indian Heart J. 2017;69(4):545-50. DOI: https://doi.org/10.1016/j.ihj.2017.07.004

Rajagopalan V, Gerdes AM. Role of thyroid hormones in ventricular remodelling. Curr Heart Fail Rep. 2015;12(2):141-9. DOI: https://doi.org/10.1007/s11897-014-0246-0

Faber J, Selmer C. Cardiovascular disease and thyroid function. In: Cardiovascular Issues in Endocrinology. S. Karger AG; 2014. p. 45–56. DOI: https://doi.org/10.1159/000360558

Abdel-Moneim A, Gaber AM, Gouda S, Osama A, Othman SI, Allam G. Relationship of thyroid dysfunction with cardiovascular diseases: updated review on heart failure progression. Vol. 19, Hormones. Springer; 2020. p. 301–9. DOI: https://doi.org/10.1007/s42000-020-00208-8

Alqahtani A, Alakkas Z, Althobaiti F, Alosaimi M, Abuzinadah B, Abdulkhalik E, et al. Thyroid dysfunction in patients admitted in cardiac care unit: Prevalence, characteristic and hospitalisation outcomes. Int J Gen Med. 2021;14:505–14. DOI: https://doi.org/10.2147/IJGM.S292750

Kamal A, Elmagd AA, Hegab AY, Aziz Rezk A, El Shorbgy MS. Correlation between the Level of Serum Free Triiodothyronine and the Degree of Myocardial Injury in Patients with Acute ST-Segment Elevation Myocardial Infarction. J Clin Exp Cardiolog. 2017;8(11):1-9. DOI: https://doi.org/10.4172/2155-9880.1000558

Leite AR, Neves JS, Borges-Canha M, Vale C, Von Hafe M, Carvalho D, et al. Evaluation of thyroid function in patients hospitalised for acute heart failure. Int J Endocrinol. 2021;2021: :6616681. DOI: https://doi.org/10.1155/2021/6616681

Kannan L, Shaw PA, Morley MP, Brandimarto J, Fang JC, Sweitzer NK, et al. Thyroid dysfunction in heart failure and cardiovascular outcomes. Circ Hear Fail. 2018;11(12): e005266. DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.118.005266

Frey A, Kroiss M, Berliner D, Seifert M, Allolio B, Güder G, et al. Prognostic impact of subclinical thyroid dysfunction in heart failure. Int J Cardiol. 2013; 168(1):300–5. DOI: https://doi.org/10.1016/j.ijcard.2012.09.064

Zamel M, Al-Shibani M. Thyroid dysfunction in patients with unstable angina. Vol. 15, Qadisiyah Medical Journal. 2019.

Caruana R, Vella S, Caruana M, Cassar A, Vassallo J, Fesc E, et al. Relationship between thyroid status and survival rates in patients with acute coronary syndrome [Internet]. Vol. 33, Malta Medical Journal. Pages; 2021.

Bruere H, Fauchier L, Brunet AB, Pierre B, Simeon E, Babuty D, et al. History of thyroid disorders in relation to clinical outcomes in Atrial fibrillation. Am J Med. 2015; 128(1):30–7. DOI: https://doi.org/10.1016/j.amjmed.2014.07.014

Selmer C, Olesen JB, Hansen ML, Lindhardsen J, Olsen AMS, Madsen JC, et al. The spectrum of thyroid disease and risk of new-onset atrial fibrillation: A large population cohort study. BMJ. 2012; 345:e7895. DOI: https://doi.org/10.1136/bmj.e7895

Hayashi T, Hasegawa T, Kanzaki H, Funada A, Amaki M, Takahama H, et al. Subclinical hypothyroidism is an independent predictor of adverse cardiovascular outcomes in patients with acute decompensated heart failure. ESC Hear Fail. 2016; 3(3):168–76. DOI: https://doi.org/10.1002/ehf2.12084

Chahine J, Ala CK, Gentry JL, Pantalone KM, Klein AL. Pericardial diseases in patients with hypothyroidism. Heart. 2019; 105(13):1027–33. DOI: https://doi.org/10.1136/heartjnl-2018-314528

Published

2023-03-21

How to Cite

1.
Khaznadar A, Baban Z. STATE OF THYROID GLAND FUNCTION IN PATIENTS ADMITTED TO CORONARY CARE UNIT. JSMC [Internet]. 2023 Mar. 21 [cited 2024 May 28];13(1):31-8. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10394

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