EVALUATION OF THYROID FUNCTION TESTS IN POSTMENOPAUSAL OSTEOPOROTIC PATIENTS IN SULAIMANI GENERAL TEACHING HOSPITAL

Authors

  • Taha O. Mahwi Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Barham Z. Sahib Kurdistan Board of Medical Specialties Candidate, Erbil, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.17656/jsmc.10165

Keywords:

Postmenopause, Osteoporosis, Thyroid, Sulaimani

Abstract

Background 

Osteoporosis is a common disorder in the elderly and postmenopausal women due to loss of estrogen that increases the risk of fracture and disability. Hyperthyroidism can cause osteoporosis either due to the effect of thyroid hormones or suppressive effect of Thyroid-stimulating hormone on the bone.

Objectives 

The aim of this study was to examine the association between serum thyroid-stimulating hormone levels and osteoporosis in Postmenopausal women in Sulaimani General Teaching hospital.

Patients and Methods

The study was done prospectively, we enrolled one hundred and sixty-two postmenopausal women who underwent Dual-energy X-ray absorptiometry scan in Sulaimani bone Densitometry department for routine health surveillance, thyroid function test was done for them after applying exclusion criteria.

Results

The mean thyroid stimulating hormone level (1.9 ± 1.7) vs (2.7 ± 2.30), body mass index and incidence of diabetes mellitus of the osteoporotic group is lower in comparison to those with normal bone mineral density.

Conclusion

In this study results suggest that low normal serum thyroid stimulating hormone level might be a potential risk factor for the osteoporosis in non-obese elderly women, however further prospective, large-scale, randomized controlled studies are warranted to fully establish these results.

References

Making the Diagnosis of Osteoporosis [Internet]. EndocrineWeb. [cited 2018 Jan 12]. Available from: https://www.endocrineweb.com/conditions/osteoporosis/making-diagnosis-osteoporosis

Osteoporosis. In: The Free Dictionary [Internet]. [cited 2018 Jan 15]. Available from: https://medical-dictionary.thefreedictionary.com/osteoporosis

Smarter Decisions. Better Care. [Internet]. UpToDate. [cited 2018 Jan 9]. Available from: https://www.uptodate.com/home

Vu MQ, Weintraub N, Rubenstein LZ. Falls in the nursing home: are they preventable? J Am Med Dir Assoc. 2004;5:401–6. DOI: https://doi.org/10.1097/01.JAM.0000144553.45330.AD

Black DM, Rosen CJ. Postmenopausal Osteoporosis. N Engl J Med. 2016;374:254–62. DOI: https://doi.org/10.1056/NEJMcp1513724

Kado DM, Browner WS, Blackwell T, Gore R, Cummings SR. Rate of Bone Loss Is Associated with Mortality in Older Women: A Prospective Study. J Bone Miner Res. 2000;15:1974–80. DOI: https://doi.org/10.1359/jbmr.2000.15.10.1974

Osteoporosis and Menopause [Internet]. WebMD. [cited 2018 Jan 15]. Available from: https://www.webmd.com/menopause/guide/osteoporosis-menopause

Organization WH. WHO scientific group on the assessment of osteoporosis at primary health care level. In: Summary meeting report. 2004. p. 5–7. Available from: www.who.int/chp/topics/Osteoporosis.pdf

Compston J, Cooper A, Cooper C, Francis R, Kanis JA, Marsh D, et al. Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas. 2009;62:105–108. DOI: https://doi.org/10.1016/j.maturitas.2008.11.022

Rattan S, Sharma R. Hormones in Ageing and Longevity. Springer; 2017. 335 p. DOI: https://doi.org/10.1007/978-3-319-63001-4

Vestergaard P, Mosekilde L. Hyperthyroidism, bone mineral, and fracture risk--a meta-analysis. Thyroid Off J Am Thyroid Assoc. 2003;13:585–93. DOI: https://doi.org/10.1089/105072503322238854

Mundy GR, Shapiro JL, Bandelin JG, Canalis EM, Raisz LG. Direct stimulation of bone resorption by thyroid hormones. J Clin Invest. 1976;58:529–34. DOI: https://doi.org/10.1172/JCI108497

Hwangbo Y, Kim JH, Kim SW, Park YJ, Park DJ, Kim SY, et al. High-normal free thyroxine levels are associated with low trabecular bone scores in euthyroid postmenopausal women. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA. 2016;27:457–62. DOI: https://doi.org/10.1007/s00198-015-3270-3

Rijn LE van, Pop VJ, Williams GR. Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women. Eur J Endocrinol. 2014;170:461–8. DOI: https://doi.org/10.1530/EJE-13-0769

Lakatos P, Foldes J, Horvath C, Kiss L, Tatrai A, Takacs I, et al. Serum Interleukin-6 and Bone Metabolism in Patients with Thyroid Function Disorders. J Clin Endocrinol Metab. 1997;82:78–81. DOI: https://doi.org/10.1210/jc.82.1.78

Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, et al. TSH is a negative regulator of skeletal remodeling. Cell. 2003;115:151–62. DOI: https://doi.org/10.1016/S0092-8674(03)00771-2

Sun L, Zhu L-L, Lu P, Yuen T, Li J, Ma R, et al. Genetic confirmation for a central role for TNF α in the direct action of thyroid stimulating hormone on the skeleton. Proc Natl Acad Sci. 2013;110:9891–6. DOI: https://doi.org/10.1073/pnas.1308336110

Noh H-M, Park YS, Lee J, Lee W. A cross-sectional study to examine the correlation between serum TSH levels and the osteoporosis of the lumbar spine in healthy women with normal thyroid function. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA. 2015;26:997–1003. DOI: https://doi.org/10.1007/s00198-014-2906-z

Acar B, Ozay AC, Ozay OE, Okyay E, Sisman AR, Ozaksoy D. Evaluation of thyroid function status among postmenopausal women with and without osteoporosis. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2016;134:53–7. DOI: https://doi.org/10.1016/j.ijgo.2015.11.025

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, Perez-Valero V, et al. Reference values for TSH may be inadequate to define hypothyroidism in persons with morbid obesity: [email protected] study. Obes Silver Spring Md. 2017;25:788–93. DOI: https://doi.org/10.1002/oby.21796

Surks MI, Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab. 2007;92:4575–82. DOI: https://doi.org/10.1210/jc.2007-1499

Management of osteoporosis in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause N Y N. 2010;17:25-54; quiz 55-56. DOI: https://doi.org/10.1097/gme.0b013e3181c617e6

NOF’s Clinician’s Guide Published by Osteoporosis International [Internet]. National Osteoporosis Foundation. [cited 2018 Jan 18]. Available from: https://www.nof.org/news/nofs-clinicians-guide-published-by-osteoporosis-international

Published

2018-10-15

How to Cite

1.
Mahwi T, Sahib B. EVALUATION OF THYROID FUNCTION TESTS IN POSTMENOPAUSAL OSTEOPOROTIC PATIENTS IN SULAIMANI GENERAL TEACHING HOSPITAL. JSMC [Internet]. 2018 Oct. 15 [cited 2024 Apr. 16];8(3):167-74. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10165

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