• Sara Jamil Nidhamalddin Hiwa Cancer Hospital, Medical Oncology Department, Sulaimani, Kurdistan Region, Iraq.
  • Jangi Shawkat Salai Hawler Medical University, College of Medicine, Rzgary Teaching Hospital, Erbil, Kurdistan Region, Iraq.
  • Hazha Abdullah Mohammed Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.



Thyroid cancer, incidence, Overdiagnosis, Clinicopathologic feature



Thyroid Cancer (TC) is the most common type of endocrine malignancy. 


To evaluate some of clinicopathologic features of thyroid carcinoma according to histopathology subtype, tumor size, age, sex and stage. 

Patients and Methods

We conducted a retrospective study that included the patients with histologically proven thyroid cancer at Hiwa hematology /oncology cancer hospital of Sulaymaniyah from 2000 to June 2018. Retrospective evaluation of 225 cases of thyroid cancer during the study period carried out. Incidence of thyroid cancer with variations based on tumor histopathology, size(≤1 cm, 1.1-2 cm, 2.1-5 cm, ≥5 cm), and stage (local, regional, metastatic), age, and sex were analyzed among the different time periods of 2004-2008, 2009-2013 and 2014-2018.


Thyroid cancer constituted (1.2%) of total solid cancers registered. A total number of 195 cases, 80 %( 155) female 20 %( 40) male of Thyroid Cancer (TC) identified from 2004-2018, only 8(4.1%) of the cases diagnosed in 2004-2008, while (142) 72.8% of the cases diagnosed in 2014-2018. Female/male ratio was 3.87. Mean age was 41.52 years, 67% of them were below age 45. Proportion of patients with tumor localized to thyroid gland (local stage) was 63%. The mean size of tumors at diagnosis was 21.71 mm at their longest diameter. Most common histologic feature was papillary thyroid cancer constituting 82% of all cases of thyroid cancer 


Papillary thyroid cancer (PTC) was the most common type of registered thyroid cancer. Thyroid cancer was more common among females. The current study showed that the disease tends to occur at a younger age, small size and more localized to thyroid gland.


Dijkstra B, Prichard RS, Lee A, Kelly LM, Smyth PPA, Crotty T, et al. Changing patterns of thyroid carcinoma. Ir J Med Sci. 2007;176(2):87–90. DOI:

Grodski S, Brown T, Sidhu S, Gill A, Robinson B, Learoyd D, et al. Increasing incidence of thyroid cancer is due to increased pathologic detection. Surgery. 2008;144(6):1038–43. DOI:

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics , 2009. A Cancer J Clin. 2009;59(04):225–49. DOI:

Sharkas G. Epidemiology of Thyroid Cancer in Jordan from 1996 to 2008. 2015;(April).

Hussain F, Iqbal S, Mehmood A, Bazarbashi S, ElHassan T, Chaudhri N. Incidence of thyroid cancer in the Kingdom of Saudi Arabia, 2000-2010. Hematol Oncol Stem Cell Ther [Internet]. 2013;6(2):58–64. Available from: DOI:

Brown RL, de Souza JA, Cohen EEW. Thyroid cancer: Burden of illness and management of disease. J Cancer. 2011;2(1):193–9. DOI:

Dal Maso L, Bosetti C, La Vecchia C, Franceschi S. Risk factors for thyroid cancer: An epidemiological review focused on nutritional factors. Cancer Causes Control. 2009;20(1):75–86. DOI:

Cardis E, Kesminiene A, Ivanov V, Malakhova I, Shibata Y, Khrouch V, et al. Risk of thyroid cancer after exposure to131I in childhood. J Natl Cancer Inst. 2005;97(10):724–32. DOI:

Burgess JR. Temporal Trends for Thyroid Carcinoma in Australia: An Increasing Incidence of Papillary Thyroid Carcinoma (1982–1997). Thyroid. 2002;12(2):141–9. DOI:

Davies L, Ouellette M, Hunter M, Welch HG. The increasing incidence of small thyroid cancers: Where are the cases coming from? Laryngoscope. 2010;120(12):2446–51. DOI:

Hodgson NC, Button J, Solorzano CC. Thyroid cancer: Is the incidence still increasing? Ann Surg Oncol. 2004;11(12):1093–7. DOI:

Morris LGT, Sikora AG, Tosteson TD, Davies L. The Increasing Incidence of Thyroid Cancer: The Influence of Access to Care. Thyroid [Internet]. 2013;23(7):885–91. Available from: DOI:

Davies L, Welch HG. in the United States , 1973-2002. 2015;295(18):7–10.

Liu S, Semenciw R, Ugnat A, Mao Y. Increasing thyroid cancer incidence in Canada , 1970 – 1996 : time trends and age-period-cohort effects. 2001;85(May):1335–9. DOI:

Chen AY, Jemal A, Ward EM. Increasing incidence of differentiated thyroid cancer in the United States, 1988-2005. Cancer. 2009;115(16):3801–7. DOI:

Hajizadeh N, Pourhoseingholi MA, Baghestani AR. Incidence rate of thyroid cancer in Iranian population , trend. 2015;2(1):12–7.

Keinan-Boker L, Silverman BG. Trends of Thyroid Cancer in Israel: 1980–2012. Rambam Maimonides Med J [Internet]. 2016;7(1):e0001. Available from: DOI:

Leenhardt L, Grosclaude P, Chérié-Challine L. Increased Incidence of Thyroid Carcinoma in France: A True Epidemic or Thyroid Nodule Management Effects? Report from the French Thyroid Cancer Committee. Thyroid. 2004;14(12):1056–60. DOI:

Dal Maso L, Lise M, Zambon P, Falcini F, Crocetti E, Serraino D, et al. Incidence of thyroid cancer in Italy, 1991-2005: Time trends and age-period-cohort effects. Ann Oncol. 2011;22(4):957–63. DOI:

D’Avanzo B, La Vecchi C, Negri E, La Vecchi C, Franceschi S, Talamini R. History of Thyroid Diseases and Subsequent Thyroid Cancer Risk. Cancer Epidemiol Biomarkers Prev. 1995;4(3):193–9.

Burgess JR, Dwyer T, McArdle K, Tucker P, Shugg D. The changing incidence and spectrum of thyroid carcinoma in Tasmania (1978-1998) during a transition from iodine sufficiency to iodine deficiency. J Clin Endocrinol Metab. 2000;85(4):1513–7. DOI:

Article O. Clinicopathological features of differentiated thyroid carcinoma referred to radioiodine therapy at Tripoli Medical Center. 2018;3–9. DOI:

Elmer P, Baydur S, Fikret A, Gucer H, Pergel A, Bedir R. Distribution of Thyroid Cancer in the Eastern Part of Turkey 27 Years After the Chernobyl Accident. 2013;4(6):230–4.

Feldt-rasmussen U. Iodine and Cancer. 2001;11(5):11–4. DOI:

Larijani B, Aghakhani S, Khajeh-dini H, Baradar-jalili R. Clinico-pathological Features of Thyroid Cancer as Observed in Five Referral Hospitals in Iran Clinico-pathological Features of Thyroid Cancer as Observed in Five Referral Hospitals in Iran. 2009;2–6.

Xue Y, Zheng S, Du H, Zhang Y, Jin W. Cr(III)-induced electrochemical advanced oxidation processes for the V2O3dissolution in alkaline media. Chem Eng J. 2017;307:518–25. DOI:

Kilfoy BA, Zheng T, Lan Q, Han X, Holford T, Hein DW, et al. NIH Public Access. 2010;21(1):127–33. DOI:

Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol - Head Neck Surg. 2014;140(4):317–22. DOI:

Du L, Wang Y, Sun X, Li H, Geng X, Ge M, et al. Thyroid cancer: Trends in incidence, mortality and clinical-pathological patterns in Zhejiang Province, Southeast China. BMC Cancer. 2018;18(1):1–9. DOI:

Cramer JD, Fu P, Harth KC, Margevicius S, Wilhelm SM. Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry. Surgery [Internet]. 2010;148(6):1147–52. Available from: DOI:

Kent WDT, Hall SF, Isotalo PA, Houlden RL, George RL, Groome PA. Increased incidence of differentiated thyroid carcinoma and detection of subclinical disease. Cmaj. 2007;177(11):1357–61. DOI:

Hall SF, Walker H, Siemens R, Schneeberg A. Increasing detection and increasing incidence in thyroid cancer. World J Surg. 2009;33(12):2567–71. DOI:

Enewold L, Zhu K, Ron E, Marrogi AJ, Peoples GE, Devesa SS. NIH Public Access. 2010;18(3):784–91. DOI:

Zhu C, Zheng T, Kilfoy BA, Han X, Ma S, Ba Y, et al. A birth cohort analysis of the incidence of papillary thyroid cancer in the United States, 1973-2004. Thyroid Off J Am Thyroid Assoc [Internet]. 2009;19(10):1061–6. Available from: DOI:

Sinnott B, Ron E, Schneider AB. Exposing the thyroid to radiation: A review of its current extent, risks, and implications. Endocr Rev. 2010;31(5):756–73. DOI:

Clegg LX, Reichman ME, Hankey BF, Miller BA, Lin YD, Johnson NJ, et al. Quality of race, Hispanic ethnicity, and immigrant status in population-based cancer registry data: Implications for health disparity studies. Cancer Causes Control. 2007;18(2):177–87. DOI:

Sado J, Kitamura T, Sobue T, Sawada N, Iwasaki M, Sasazuki S, et al. Risk of thyroid cancer in relation to height, weight, and body mass index in Japanese individuals: a population-based cohort study. Cancer Med. 2018;7(5):2200–10. DOI:

Xhaard C, Rubino C, Cléro E, Maillard S, Ren Y, Borson-Chazot F, et al. Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in young women in France: A population-based case-control study. Am J Epidemiol. 2014;180(10):1007–17. DOI:

Yu Q, Lv X, Liu K, Ma D, Wu Y, Dai W, et al. Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018;2018. DOI:



How to Cite

Nidhamalddin S, Salai J, Mohammed H. CLINICOPATHOLOGIC FEATURES OF THYROID CANCER IN SULAIMANI, 2004-2018. JSMC [Internet]. 2019 Dec. 21 [cited 2024 May 28];9(4):337-45. Available from:

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