TOPICAL TIMOLOL EYE DROP SOLUTION FOR THE TREATMENT OF FISSURES IN PATIENTS WITH HAND DERMATITIS

Authors

  • Darsim Mohammed Abdalla College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.17656/jsmc.10360

Keywords:

Timolol eye drop solution, Hand dermatitis, Fissures

Abstract

Background 

Some patients with chronic hand dermatitis may complain of painful and itchy fissures; in some cases, the fissures are reluctant to conventional therapies of hand dermatitis.

Objectives 

To evaluate the efficacy and safety of topical timolol eye drop 0.05% solution for the treatment of fissures in patients with hand dermatitis.

Patients and Methods

In this therapeutic trial, twenty-two cases with chronic hand dermatitis whose hand fissures are unresponsive to conventional therapies are treated with a single daily application of topical timolol eye drop 0.05% solution on the fissures for three weeks; those with complete disappearance of the fissures and symptoms are regarded as complete response, those with a decrease in size and number of fissures with partial or no improvement of symptoms are regarded as a partial response, and those with no change in size and number of fissures with no improvement in symptoms are regarded as no response, search of any side effect done.

Results

The age of the patients ranged from 16-39 years, and the majority were females. Eleven patients (50%) showed complete response, eight patients (36.4%) had a partial response, and three patients (13.6%) had no response. Patients with a single fissure had a statistically significant better response than those with multiple fissures. No, local or systemic side effects were recorded. 

Conclusion

Topical timolol solution is an effective and safe choice for treating fissures in patients with hand dermatitis.

References

Hald M, Berg ND, Elberling J, Johansen JD. Medical consultations concerning the severity of hand eczema in the general population. Br J Dermatol. 2008; 158(4): 773-7. DOI: https://doi.org/10.1111/j.1365-2133.2007.08431.x

Magina S, Barros MA, Ferreira JA, Mesquita-Guimaraes J. Atopy, nickel sensitivity, occupation, and clinical patterns in different types of hand dermatitis. Am J Contact Dermat. 2003; 14(2):63-8. DOI: https://doi.org/10.1097/01206501-200306000-00003

Diepgen TL, Andersen KE, Chosidow O, Coenraads PJ, Elsner P, English J, et al. guidelines for diagnosis, prevention and treatment of hand eczema. J Dtsch Dermatol Ges. 2015; 13(1): 1-22. DOI: https://doi.org/10.1111/ddg.12510_1

Heede NG, Thyssen JP, Thuesen BH, Linnegerg A, Johansen JD. Predictive factors of self-reported hand eczema in adult Danes: a population-based cohort study with 5-year follow-up. Br J Dermatol. 2016; 175(2): 287-95. DOI: https://doi.org/10.1111/bjd.14476

Coenraads pJ. Hand eczema. N Engl J Med. 2012; 367(19):1829-1837. DOI: https://doi.org/10.1056/NEJMcp1104084

Grando SA, Pittelkow MR, Schallreuter KU. Adrenergic and cholinergic control in the biology of the epidermis: physiological and clinical significance. J Invest Dermatol. 2006; 126(9):1948-1965. DOI: https://doi.org/10.1038/sj.jid.5700151

Cahn BA, Kaur R, Hirt PA, Tchanque-Fossuo C, Dahle SE, Kirsner RS, et al. Use Topical Timolol Maleate as Re-Epithelialization Agent for Treatment of Recalcitrant Wounds of Varying Etiologies. J Drugs Dermatol. 2020; 19(12):1252-6. DOI: https://doi.org/10.36849/JDD.2020.5306

Denda M, Fuziwara S, Inoue K. Beta-Adrenergic receptor antagonists accelerate skin recovery and reduce epidermal hyperplasia induced by barrier disruption. J Invest Dermatol. 2003; 121(1):142-148. DOI: https://doi.org/10.1046/j.1523-1747.2003.12310.x

Pullar CE, Manabat-Hidalgo CG, Bolaji RS, Isseroff RR. ß-adrenergic receptor modulation of wound repair. Pharmacol Res. 2008; 58(2):158-164. DOI: https://doi.org/10.1016/j.phrs.2008.07.012

Pullar CE, Isseroff RR. Cyclic AMP mediates keratinocyte directional migration in an electric field. J Cell Sci.2005; 118(pt9)2023-2034. DOI: https://doi.org/10.1242/jcs.02330

Abdulrassol FA, Katof WM. Hand dermatitis among patients visited the dermatology clinic of Al-Sadder teaching hospital, Misan province. Al-Mustansiriyah Journal of Science. 2018; 29(1):44-48. DOI: https://doi.org/10.23851/mjs.v29i1.231

Mollerup A, Veien NK, Johansen JD. An analysis of gender differences in patients with hand eczema-everyday exposure, severity, and consequences. Contact Dermatitis. 2014; 71(1):44-48. DOI: https://doi.org/10.1111/cod.12206

Power M. Topical timolol in chronic, recalcitrant hand eczema fissures. J Am Acad Dermatol. 2021; 84(3):e125-e6. DOI: https://doi.org/10.1016/j.jaad.2020.04.070

Braun LR, Lamel SA, Richmond NA, Krisner RS. Topical Timolol for Recacitrant Wounds. JAMA Dermatology. 2013; 149(12):1400-2 DOI: https://doi.org/10.1001/jamadermatol.2013.7135

Published

2022-06-21

How to Cite

1.
Abdalla D. TOPICAL TIMOLOL EYE DROP SOLUTION FOR THE TREATMENT OF FISSURES IN PATIENTS WITH HAND DERMATITIS. JSMC [Internet]. 2022 Jun. 21 [cited 2024 Apr. 23];12(2):189-95. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10360

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