• Rawaz Salah Daood Kurdistan Board Medical Studies Candidate, Erbil, Kurdistan Region, Iraq.
  • Jangy Shawkat Salaye Program Director, Kurdistan Medical Board Oncology, Erbil, Kurdistan Region, Iraq.




Gastric cancer, Blood group, Kurdish population



Many studies have been done of relationship between blood group and cancers. 


To evaluate the relationship between ABO blood group system and the risk of gastric cancer with its histopathological features among Kurdish population by case-control study.

Materials and Methods

In our retrospective case-control study, 194 cases of gastric cancer were enrolled from March 2013 to October 2017 The patients were of Kurdish ethnicity, data on age, sex, hisopathological result, blood group, grade and stage at diagnosis were collected, association with ABO blood group and gastric cancer were assessed.


This study showed that blood group A might be a risk factor of gastric cancer in both males and females. The intestinal type adenocarcinomas were the most frequent hisopathological subtype of gastric carcinoma among blood group A. Grade 3 of differentiation found to be most frequent in blood group A patients (20.1%).


Individuals with blood group A has a higher risk of developing gastric cancer in their lifetime and their disease would be of high grade which might predict poor prognosis, while people with blood group AB have the lowest risk of developing gastric cancer.


Ferro A, Peleteiro B, Malvezzi M, Bosetti C, Bertuccio P, Levi F, et al. Worldwide trends in gastric cancer mortality (1980-2011), with predictions to 2015, and incidence by subtype. Eur J Cancer. 2014; 50:1330–44. DOI: https://doi.org/10.1016/j.ejca.2014.01.029

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. DOI: https://doi.org/10.3322/caac.20107

Lauwers GY, Carneiro F, Graham DY. Gastric carcinoma. In: Bowman FT, Carneiro F, Hruban RH, eds. Classification of Tumours of the Digestive System. Lyon:IARC;2010.

Tsugane, S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci. 2005, 96, 1–6. DOI: https://doi.org/10.1111/j.1349-7006.2005.00006.x

Murakami, K.; Kodama, M.; Fujioka, T. Latest insights into the effects of Helicobacter pylori infection on gastric carcinogenesis. World J. Gastroenterol. 2006, 12, 2713–2720. DOI: https://doi.org/10.3748/wjg.v12.i17.2713

Kelley, J.R.; Duggan, J.M. Gastric cancer epidemiology and risk factors. J. Clin. Epidemiol. 2003, 56, 1–9. DOI: https://doi.org/10.1016/S0895-4356(02)00534-6

Aird, I.; Bentall, H.H.; Roberts, J.A. A relationship between cancer of stomach and the ABO blood groups. Br. Med. J. 1953, 1, 799–801 DOI: https://doi.org/10.1136/bmj.1.4814.799

Hems, G. Epidemiological characteristics of breast cancer in middle and late age. Br. J. Cancer. 1970, 24, 226–234. DOI: https://doi.org/10.1038/bjc.1970.26

Levitan R, Razis DV, Diamond HD, ABO blood groups in Hodgkin’s disease. Craver LF (1959). 22, 12-9. DOI: https://doi.org/10.1159/000205756

Lewis JG, Woods AC. The ABO and Rhesus blood groups in patients with respiratory disease. 1961,Tubercle, 42, 362-5. DOI: https://doi.org/10.1016/S0041-3879(61)80124-4

Jaff MS. ABO and rhesus blood group distribution in Kurds. Journal of blood medicine. 2010; 1:143-146. DOI: https://doi.org/10.2147/JBM.S12262

Khoshnaw Najmaddin, Mohammed Hazha, Ahmed Dana. Patterns of Cancer in Kurdistan - Results of Eight Years Cancer Registration in Sulaymaniyah Province-Kurdistan-Iraq. Asian Pacific journal of cancer prevention: APJCP.2016, 16. 8525-8531. DOI: https://doi.org/10.7314/APJCP.2015.16.18.8525

Katrina F. Brown, Harriet Rumgay, Casey Dunlop et al. The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015.

Gustaf Edgren, Henrik Hjalgrim, Klaus Rostgaard, Rut Norda, Agneta Wikman, Mads Melbye, and Olof Nyre´n, Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type.(2010) 172:1280–1285. DOI: https://doi.org/10.1093/aje/kwq299

Song HR, Shin MH, Kim HN et al Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population. Gastric Cancer.2013 16:254–260. DOI: https://doi.org/10.1007/s10120-012-0176-z

Zhiwei Wang, Lei Liu , Jun Ji, Jianian Zhang, Min Yan, Jun Zhang, Bingya Liu, Zhenggang Zhu and Yingyan Yu, ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis, Int. J. Mol. Sci. 2012, 13. DOI: https://doi.org/10.3390/ijms131013308

Bai-Lin Zhang1&, Na He &, Yu-Bei Huang , Feng-Ju Song , Ke-Xin Chen ,ABO Blood Groups and Risk of Cancer: a Systematic Review and Meta-analysis, Asian Pac J Cancer Prev.2014, 15 (11), 4643-4650. DOI: https://doi.org/10.7314/APJCP.2014.15.11.4643

Sievers, M.L. Hereditary aspects of gastric secretory function; race and ABO blood groups in relationship to acid and pepsin production. Am. J. Med. 1959, 27, 246–255. DOI: https://doi.org/10.1016/0002-9343(59)90345-6

Roberts, J.A. Blood groups and susceptibility to disease: A review. Br. J. Prev. Soc. Med. 1957, 11, 107–125. DOI: https://doi.org/10.1136/jech.11.3.107

Hoskins, L.C.; Loux, H.A.; Britten, A.; Zamcheck, N. Distribution of ABO blood groups in patients with pernicious anemia, gastric carcinoma and gastric carcinoma associated with pernicious anemia. N. Engl. J. Med. 1965, 273, 633–637. DOI: https://doi.org/10.1056/NEJM196509162731204

Qiu, MZ., Zhang, DS., Ruan, DY. et al, A relationship between ABO blood groups and clinicopathologic characteristics of patients with gastric adenocarcinoma in China,. Med Oncol (2011) 28(Suppl 1): 268 DOI: https://doi.org/10.1007/s12032-010-9735-5

Devita, Hellman, and Rosenbergs , Cancer principle and practice of oncology,10th ed.Newyork 2015. P613-650.

Zheng H, Takahashi H, Murai Y, et al. Pathobiological characteristics of intestinal and diffuse type gastric carcinoma in Japan: an immunostaining study on the tissue microarray. Journal of Clinical Pathology. 2007; 60(3):273-277. DOI: https://doi.org/10.1136/jcp.2006.038778

Franchini M, Liumbruno GM, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood Transfusion. 2016; 14(5):434-440.



How to Cite

Daood R, Salaye J. HISTOPATHOLOGICAL CHARACTERISTICS OF GASTRIC CARCINOMA AND ITS RELATION WITH ABO BLOOD GROUP IN KURDISH PEOPLE. JSMC [Internet]. 2018 Dec. 21 [cited 2024 Apr. 23];8(4):261-6. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10177

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