The Effect of Vitamin D3 Status Correction Through Supplementation on Glycemic Control and Hyperlipidemia in Type 2 Diabetes

Volume 16 , Issue 1 , July 2026

Authors

rebin rajab 1 ; Taha Osman Assad Mahwi 2

1 Sulaimany university department of clinical science

2 university of sulaimani/ college of medicine

DOI logo 10.17656/jsmc.10513

Keywords

Abstract

Background and Objectives: Vitamin D deficiency is common in patients with type 2 diabetes mellitus (T2DM) and may exacerbate poor glycemic control and dyslipidemia. This study aimed to evaluate the efficacy of high-dose vitamin D3 supplementation in improving glycemic control and lipid parameters in vitamin D-deficient adults with T2DM. Methods: A double-blind, randomized, placebo-controlled clinical trial was conducted at the Diabetic and Endocrine Center in Sulaimanyh. A total of 180 adults (aged 40–70 years) with T2DM (HbA1c 7–10%) and vitamin D deficiency (<20 ng/mL) were randomized to receive either vitamin D3 5000 IU/day (n=91) or placebo (n=89) for three months, followed by one month of follow-up. Primary outcome was change in HbA1c; secondary outcomes were fasting blood glucose (FBG), lipid profile, and serum 25(OH)D. Results: After intervention, the active D3 group showed significant reductions in HbA1c (7.95 ± 0.67% to 7.68 ± 0.69%, p=0.001), FBG (165.64 ± 18.7 to 161.41 ± 19.6 mg/dL, p=0.001), triglycerides (184.82 ± 28.1 to 178.65 ± 27.6 mg/dL, p=0.001), cholesterol (184.15 ± 22.2 to 179.54 ± 20.5 mg/dL, p=0.001), and LDL (113.69 ± 14.7 to 109.59 ± 13.9 mg/dL, p=0.001). HDL increased significantly (35.27 ± 3.2 to 40.07 ± 2.9 mg/dL, p=0.001). Serum 25(OH)D rose from 12.9 ± 2.9 to 34.1 ± 5.3 ng/mL (p=0.001). In contrast, placebo participants demonstrated deterioration in glycemic and lipid markers (all p≤0.001). Conclusion: High-dose vitamin D3 (5000 IU/day) significantly improved glycemic control, lipid parameters, and serum vitamin D3 status in deficient adults with T2DM

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  • First online2 July 2026
  • Published at2 July 2026

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