PREDNISOLONE VERSUS COMBINATION OF PREDNISOLONE AND IVIG IN TREATMENT OF ACUTE IDIOPATHIC THROMBOCYTOPENIA AMONG CHILDREN

Volume 14 , Issue 3 , September 2024 , Pages 287-293

Authors

Siamand Yahya Salim 1

1 Lecturer in College of Medicine, HMU, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10476

Keywords

Abstract

Background
Immune thrombocytopenia (ITP) is a medical situation appearing from animmunological reaction, resulting
in a decreased platelet count and improved susceptibility to bleeding. Intravenous immunoglobulin (IVIG) in
conjunction with corticosteroids, such as prednisolone, is often used as the first medicine practice for children.
Nevertheless, there needs to be more information corresponding to the effectiveness of hybrid treatment to
corticosteroids alone.
Objectives
In this study we aim to compare the outcomes of treating patients with prednisoloneas a sole treatment with
the combination of prednisolone and IVIG in treating acute immune thrombocytopenic purpura in children.
Patients and Methods
In this randomized controlled experiment, 42 pediatric patients interpreted with immune thrombocytopenic
purpura (ITP) were comprised. These children were unsystematically allocated to two groups: one group got
intravenous immunoglobulin (IVIG) in combination with prednisolone (n=21), while the other group accepted
prednisolone alone (n=21). Platelet counts were measured at baseline, day 3, and week 2.
Results
The study’s results demonstrate that the average baseline platelet count was 17.52±4.59 x 109/L, and no
notable difference was seen between the groups. On the third day of the study, the hybrid group displayed a
statistically meaningful increase in platelet recovery (113.71±26.3 x 109/L) as compared to the group receiving
prednisolone alone (80.90±18.09 x 109/L, p<0.001). In the second week, the group acquiring the combined
treatment had significantly more significant increases in platelet counts (207.71±45.26 x 109/L) compared to
those receiving prednisolone alone (121.62±26.33 x 109/L, p<0.001).
Conclusion
the management of a combination of intravenous immunoglobulin (IVIG) and prednisolone resulted in a more
immediate and considerable elevation in platelet levels as compared to the use of prednisolone alone as a
monotherapy in pediatric patients recently analyzed with immune thrombocytopenic purpura (ITP). The results
of this study provided proof in favor of the use of IVIG in combination with steroids as a more compelling
first treatment option for reducing the risks associated with bleeding. The demographic characteristics and
treatment results are consistent with previous empirical discoveries.

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