EFFECT OF SGLT2 INHIBITORS ON THE INCIDENCE OF URINARY TRACT INFECTIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Volume 14 , Issue 3 , September 2024 , Pages 277-285

Authors

Zagros Ghaffor Rashid 1

1 Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10475

Keywords

Abstract

Background
The incidence of urinary tract infection (UTI) among patients with type 2 diabetes mellitus (T2DM) who
received Sodium Glucose Cotransporter-2 (SGLT-2)inhibitors is disputable. Therefore, we performed this
study.
Objectives
To investigate the effect of SGLT-2 inhibitors on the incidence of UTI among patients with T2DM and to find
out the factors related to high risk of UTI.
Materials and Methods
This is a prospective cohort study that included 200 patients with T2DM attended private medical clinics in
Sulaimanyah city, Kurdistan region, Iraq between 1st October 2022 and 30th April 2023. The participants
were split into Non-SGLT-2 inhibitors & SGLT-2 inhibitors groups to collate the incidence of UTI.
Results
The incidence rate of UTI in the SGLT-2 inhibitors group was 17%, while it was 3% in the Non-SGLT-2
inhibitors group. Although the incidence rates of UTI were different between Empagliflozin and Dapagliflozin
treatment (70.6% and 29.4% respectively) statistically it was near significant (P value 0.06). Patients who
received SGLT-2 inhibitors had a 5.67-fold higher risk of UTI in comparison to those who were on NonSGLT-2 inhibitors (95% CI 1.71-18.73). Furthermore, the only significant risk factor for UTI found in this
research was a high level of glycosylated Haemoglobin (HbA1c).
Conclusion
This study showed higher UTI incidence in patients with T2DM using Empagliflozin and Dapagliflozin
compared with Non-SGLT-2 inhibitors. Furthermore, patients with high HbA1c >9% had a compelling higher
risk of UTI when receiving SGLT-2 inhibitors.

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  • Published at21 September 2024

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