THE VALUE OF USING DAPAGLIFLOZIN SUPPLEMENTATION IN THE MANAGEMENT OF TYPEII-DIABETES WITH HYPERTENSION: A PRELIMINARYCROSS-SECTIONAL STUDY IN SULAIMANI- IRAQ

Volume 14 , Issue 3 , June 2024 , Pages 251-262

Authors

Vian Ahmed Wasta Esmail 1

1 Department of Clinical Pharmacy, College of Pharmacy,, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10472

Keywords

Abstract

Background
Dapagliflozin is known to have pleiotropic effects that extend to the cardiovascular system and various body
organs. The presence of concomitant illnesses and complications such as hypertension with type 2 diabetes
may change the magnitude of these pleotropic effects.
Objectives
to test the hypothesis that Dapagliflozin supplementation is of benefit in type 2 diabetes associated with
hypertension compared to type 2 diabetes without hypertension.
patients and Methods
In this cross-sectional study, 37 diabetic patients who were receiving 10 mg of Dapagliflozin/day plus
insulin and/or oral antidiabetic agents were divided into two groups: Group I (n = 15) included diabetic
normotensive patients, while group II (n = 22) were diabetic hypertensive patients who were receiving one or
two antihypertensive drugs as well. Anthropometric measurements, blood pressure, arterial stiffness index,
myocardial work stress, hematological indices, serum fasting lipid profile, glycaemic indices, renal function
tests, and Echocardiography for measuring Left Ventricular Ejection Fraction were recorded.
Results
Hypertension as a concomitant illness resulted in significant differences in body mass index (P= 0.045), white
blood cells (P=0.003), platelet count (P = 0.011), fasting blood glucose (P= 0.036), serum triglycerides (P=
0.003), and triglyceride- glucose index (P = 0.001).
Conclusion
The pleotropic effects of Dapagliflozin on selected organs and blood cells were affected by concomitant
hypertension and its efficacy as an oral antidiabetic agent declined in the presence of high blood pressure but
maintained renal function and produced a positive impact on the haematological indices. Additionally, the
antihypertensive efficacy of Dapagliflozin decreases as blood glucose and triglycerides increase.

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