THE EFFECT OF VITAMIN D SUPPLEMENTATION ON ALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Volume 14 , Issue 2 , June 2024 , Pages 215-221

Authors

Bnar Sardar Saida 1 ; Dana Ahmed Sharif 2

1 Nephrology board trainee at Kurdistan Higher Council of Medical Specialties, Sulaimani Center, Kurdistan Region, Iraq.

2 Head of department of clinical science, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10468

Keywords

Abstract

Background
Proteinuria is the hallmark of diabetic kidney disease. Patients with Diabetes mellitus is deficient in Vitamin
D compared to normal people, which has some beneficial effects on albuminuria.
Objectives
To assess the effect of Vitamin D supplementation on albuminuria in diabetic patients.
Materials and Methods
In this prospective case-control study, we collected 80 diabetics with albuminuria from the 1st of May, 2022 to
the 1st of September, 2022 at Shar Teaching Hospital, Sulaimaniyah, Iraq. All patients had type two diabetes
mellitus, albuminuria (urinary Albumin/Creatinine of > 30 mg/g, morning sample, twice) and Vitamin D
deficiency (less than 30 ng/ml). All were on Angiotensin-converting enzyme inhibitors or Angiotensin two
receptor blockers. They were divided into 2 groups: Cholecalciferol supplementation is given in group one
(50000 IU weekly for 2 months), and no treatment is given in group two. After eight weeks: the urine Albumin/
Creatinine ratio and serum vitamin D were measured in both groups.
Results
All patients completed the study course. Those with vitamin D supplementation showed a significant lowering
of albuminuria compared to control (31% vs 3% reduction, p value 0.001), which was parallel to the significant
increase in the vitamin D level in the treatment arm (≈ 6.25 ng/ml vs 0.5 ng/ml in the control arm). The
response was slower in smokers in the treatment group. Baseline status of blood glucose, gender and age did
not affect the outcome.
Conclusion
Vitamin D deficiency may exacerbate albuminuria and supplementation has beneficial effects on proteinuria
in diabetic nephropathy. The interference of inflammatory process and plasma renin activity can explain the
effect. Further studies with larger sample sizes and longer duration may be needed for confirmation of the
efficacy.

Statistics
  • Article view872
  • Downloads6
  • Published at21 June 2024

  • RIS
  • BibTeX
  • EndNote
  • Mendeley
  • APA (7th edition)
  • MLA (9th edition)
  • Chicago
  • Harvard
  • IEEE
  • Vancouver