HISTOPATHOLOGICAL AND BIOLOGICAL BEHAVIOR OF BREAST CANCER IN ELDERLY KURDISH WOMEN

Volume 13 , Issue 4 , July 2025 , Pages 411-421

Authors

Kamal Ahmad Saeed 1 ; Shewaz Abdulla Faqe Salih 2

1 Department of Surgery, College of Medicine, Univeristy of Sulaimani, Kurdistan Regio, Iraq.

2 Shar Hospital, Sulaimani, Ministry of Health, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10436

Keywords

Abstract

Background
Breast cancer is the most prevalent cancer in women, with incidence and mortality increasing markedly with
age.
Objective
This study aimed to determine the clinicopathological features and biological behaviors of breast cancer
patients in elderly Kurdish women.
Materials and Methods
We retrospectively evaluated the clinicopathological and biological features of breast cancer in elderly
Kurdish women (≥65 years; n = 143) between 2015 and 2021. This cross-sectional study was carried out at
the Hiwa haematology-oncology hospital in the Iraqi Kurdistan province of Sulaymaniyah. According to age,
patients were divided into groups 1 (65–74 years, N=112) and 2 (75 years or older, N=31). Clinicopathological
characteristics including tumor histology, histological grade, estrogen (ER) and progesterone (PR) and human
epidermal growth factor 2 (HER2) status, molecular subtypes, tumor sizes (T), lymph node status (N),
lymphovascular invasion (LVI), distant metastasis (M), clinical stage, and tumor focality with laterality were
all assessed.
Results
The mean age of the study population was 71.4. The most common histopathological type of breast cancer
was invasive ductal carcinoma, followed by invasive lobular carcinoma and papillary carcinoma. Hormone
receptor positivity rates were high, and the HER2 status was mostly negative. Luminal A and B (79.7%) were
the most frequent types; triple negative (15.2%) was high. The mean age was 72.3 for group 1 (range 65-74)
and 84.9 for group 2 (range 75 and older). Excluding symptomatic presentation, progesterone receptor status,
and metastasis category, no statistically signifi cant difference was found between the two groups. At the time
of presentation, every patient in group 2 had symptoms (p=0.047).
Conclusion
Our study results showed that breast cancer in the elderly (≥65 years) patients in Kurdish seemed to have more
aggressive clinical, pathological, and biological characteristics than older women worldwide.

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  • First online26 July 2025
  • Published at26 July 2025

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