TREATMENT OUTCOMES OF UTERINE CARCINOMA: A SINGLE INSTITUTION RETROSPECTIVE STUDY

Volume 13 , Issue 3 , March 2025 , Pages 283-291

Authors

Bakhan Mahmood Karim 1 ; Chro Najmaddin Fattah 2 ; Jalil Salih Ali 1

1 Radiation oncology, Zhianawa Cancer Center, Kurdistan Region, Iraq.

2 College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10422

Keywords

Abstract

Background
Endometrial cancer has a lifetime risk of 2.6% for women living in industrialized countries and it is the most
prevalent kind of cancer diagnosed in those regions. In terms of gynecologic cancer-related deaths, it ranks
after ovarian and cervical cancer as the third most common cause.
Objectives
To evaluate endometrial cancer patients’ long-term treatment outcomes, including disease-free survival and
overall survival, as well as to pinpoint independent predictive markers.
Materials and Methods
At the Zhianawa Cancer Center, a retrospective analysis was conducted. All patients who had been referred for
radiation therapy between March 2009 and January 2019 were included in the research, except those who had
distant metastases. In the end, 89 patients were included. Using the Kaplan-Meier technique, overall survival
and disease-free survival were calculated, and the significance of the variations across curves was evaluated
using the log-rank test.
Results
All patients underwent surgery, 96.6% received adjuvant radiotherapy, and 42.7% received concomitant
chemotherapy. The 5-year and 10-year disease-free survivals were 62.9% and 56.2%, and the overall 5-year
and 10-year survivals were 74.2% and 66.3% respectively. The statistically significant variables impacting
disease-free survival were lymphovascular invasion and marginal status, and the only statistically significant
prognostic variable affecting overall survival was the FIGO stage.
Conclusion
In this analysis, we concluded that uterine cancer has a good prognosis, and its outcome was influenced by
stage, lymphovascular space invasion, and surgical marginal status.

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  • Published at7 March 2025

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