OXIDATIVE STRESS STATUS IN SERUM OF MIGRAINEURS IN ERBIL CITY-IRAQ

Volume 13 , Issue 3 , March 2025 , Pages 227-235

Authors

Abdulrahman Aziz Rasoul 1

1 Kurdistan Board of Medical Specialties (KBMS), Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10415

Keywords

Abstract

Background
Migraine is one of the neurological disorders whose etiology remains elusive. Increased oxidative stress may
be associated with migraine. Oxidative stress may play an important role in patients with migraine, and it can
reflect the ability of tissues to free radical damage.
Objectives
To determine the oxidative stress markers levels in migraine patients’ serum. This study also included the use
of oxidative stress indicators to diagnose migraines.
Materials and Methods
A total of 180 subjects (100 migraines and 80 healthy controls) were included in the study; nitric oxide (NO)
metabolites, malondialdehyde (MDA), and superoxide dismutase (SOD) were measured in serum.
Results
In migraineurs, the levels of SOD, NO, and MDA were significantly higher when compared to healthy controls.
There was a significant positive correlation between NO with MDA and SOD. Roc curve showed that NO was
a useful marker for the diagnosis of migraine. Binary logistic regression documented that NO was negatively
affect the life of migraineurs.
Conclusion
Therefore, oxidative stress has a role in the pathophysiology of migraine, and NO may serve as a useful
diagnostic marker in migraine patients.

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  • Published at7 March 2025

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