SURVIVAL OUTCOMES AMONG PATIENTS WITH HIGH-GRADE GLIOMA: A SINGLE INSTITUTION RETROSPECTIVE STUDY

Volume 13 , Issue 3 , March 2025 , Pages 215-226

Authors

Hawbir Ahmed Gharib 1 ; Ari Sami Hussain Nadhim 2 ; Bamo Mohammed Muhsin 3

1 Zhianawa Cancer Center, Sulaimaniyah, Kurdistan Region, Iraq.

2 College of Medicine, University of Sulaimani, Kurdistan Region, Iraq

3 College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10414

Keywords

Abstract

Background
The prognosis for glioma patients is poor, despite recent advances in diagnosis and treatment. Understanding
Glioma’s clinical characteristics and predictive factors is crucial for patient treatment and management.
Objectives
To assess the survival duration of HGG patients at a single facility and to discover clinical determinants of
treatment outcome in HGG treated with a combined modality approach in Zhianawa Cancer Center.
Patients and Methods
This study included 133 patients with high-grade gliomas diagnosed between January 2015 and January 2020;
these patients were referred to the Zhianawa Cancer Center. A retrospective analysis of the clinical data
included survival outcomes, tumour characteristics, and demographic information. While the Cox regression
model was used for the evaluation of multivariate data to look at the risk factors for mortality, on the other
hand, survival data were analyzed using Kaplan-Meier curves with a log-rank test.
Results
In this particular patient cohort, grade IV glioma (83.9%), grade III glioma (16.1), and glioblastoma (81.4%)
were the most common pathological types. A poor prognosis was associated with not using temozolomide,
having a Karnofsky Performance Score (KPS) of less than 70%, and not receiving radiotherapy. Univariate
analysis showed low KPS (70) to increase the risk of mortality. Patients who had radiotherapy with normal
fractionation, concurrent chemotherapy, and radiotherapy adjuvant chemotherapy had the highest overall
survival rates.
Conclusion
Mortality was significantly related to aging, absence of seizures, presence of motor alteration, pathological
grade IV gliosarcoma, glioblastoma multiform, and non-standard radiation dose.

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  • Published at7 March 2025

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