ASSOCIATION BETWEEN ANTI-THYROID PEROXIDASE ANTIBODY AND RECURRENT MISCARRIAGE

Volume 13 , Issue 2 , July 2025 , Pages 147-153

Authors

Sara Ismail Mahmood 1 ; Chro Najmaddin Fattah 2

1 Sulaimani Maternity Teaching Hospital, Ministry of Health, Kurdistan Region, Iraq.

2 Department of Gynecology and Obstetrics, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10407

Keywords

Abstract

Background
Thyroid disease is the second most commonly affected disease in childbearing women, after diabetes, and
thyroid autoimmunity in pregnancy has been connected with adverse pregnancy outcomes such as miscarriage,
recurrent miscarriage, preterm birth, and low intelligence.
Objectives
The study seeks to determine whether there is a significant correlation between anti-thyroid peroxidase
antibodies and unexplained recurrent miscarriages.
Patients and Methods
A Case-control study was conducted on 124 participants, 62 women who had experienced unexplained
recurrent miscarriage and 62 healthy women without a history of miscarriage, from 11.9.2021 until 10.6.2022
in the outpatient and emergency department of Sulaimani Maternity Teaching Hospital and some private
clinics in Sulaimani City/Kurdistan Region /Iraq, and screening for TSH and anti–thyroid peroxidase antibody
are done for both groups.
Results
The prevalence of positive anti-thyroid peroxidase antibody in women with recurrent miscarriage was 19.4 %,
while in women without miscarriage was 6.5% (which is considerably higher in cases than in women without
recurrent miscarriage with a p-value of 0.03 and an odd ratio of 3.48 (95% CI; 1.06-11.48).
Conclusion
There is a statistically significant relationship between anti-thyroid peroxidase antibodies and recurrent
miscarriage. We recommend screening for TSH and thyroid antibodies for women with recurrent miscarriages
and further studies on the effect of levothyroxine therapy for euthyroid women with antibody positive.

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  • First online26 July 2025
  • Published at26 July 2025

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