ASSOCIATION OF TROPONINS WITH SEX HORMONES IN STABLE HEMODIALYSIS PATIENTS

Volume 13 , Issue 2 , July 2025 , Pages 135-145

Authors

Dereen Najat Mohammed 1 ; Terza Seerwan Ibrahim 2

1 Department of Chemistry, College of Science, University of Sulaimani, Kurdistan Region, Iraq.

2 a Department of Chemistry, College of Science, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10406

Keywords

Abstract

Background
Cardiovascular events are one of the major causes of death in dialysis. Usually, troponins are regarded gold
standard for detecting cardiovascular complications. In addition, studies have confirmed a difference between
men and women regarding cardiovascular and renal diseases.
Objectives
To investigate the relation between troponins (Hs-TnT) and biomarkers, including sex hormone binding
globulin (SHBG), estradiol, total and free testosterone, ferritin, Albumin, CRP and estimated glomerular
filtration rate (eGFR) in hemodialysis.
Patients and Methods
Sixty-one hemodialysis patients were enrolled in this study. Hs-cTnT, cTnI, total testosterone, free testosterone,
SHBG, estradiol, Albumin, CRP, ferritin, urea and creatinine were estimated.
Results
Hs-cTnT was associated with Albumin (R=-0.3; P=0.01). Troponin showed no association with the rest of the
markers. The mean values in the dialysis group were: Hs-cTnT 93.8 pg/ml; ferritin 222.1 µg/l; albumin 4.18
g/dl; CRP 18.4 mg/l; urea 143.3 mg/dl; creatinine 9.4 mg/dl; total testosterone 1.46 ng/ml; free testosterone
28.75 pg/ml when compared to the control group, the differences between serum values in dialysis group were
significant P < 0.05. The rest of the biomarkers showed no significant differences.
Conclusion
The most interesting finding was a negative association of Albumin with Hs-cTnT, indicating the possible use of
albumin-adjusted Hs-cTnT rather than troponin alone to better predict critical cardiac events in hemodialysis.
Troponin did not associate with SHBG, estradiol and testosterone hormones, possibly indicating no obvious
role of these hormones in troponin regulation. Estimated GFR levels showed no correlation, suggesting
troponin might be further degraded before renal elimination.

Statistics
  • Article view457
  • Downloads0
  • First online26 July 2025
  • Published at26 July 2025

  • RIS
  • BibTeX
  • EndNote
  • Mendeley
  • APA (7th edition)
  • MLA (9th edition)
  • Chicago
  • Harvard
  • IEEE
  • Vancouver