PREVALENCE OF HLA-B27 AMONG PATIENTS WITH ANKYLOSING SPONDYLITIS IN SULAIMANI PROVINCE

Volume 14 , Issue 1 , March 2024 , Pages 9-16

Authors

Chawarwan Qassim Muhammed 1 ; Raouf Rahim Mirza 2

1 Rheumatology Department, Shaheed Hemin Hospital, Biology Center, Kurdistan Region, Iraq.

2 College of Medicine, University of Sulaimani, Kurdistan Region,Iraq.

DOI logo 10.17656/jsmc.10445

Keywords

Abstract

Background
Ankylosing spondylitis is a prototype of a spondyloarthritis family of diseases characterized by chronic
infl ammation of the sacroiliac joints, spine, and entheses, mostly affecting young men. The prevalence of AS
varies with the frequency of HLA-B27 in the population. A strong association between AS and the HLA-B27
haplotype has been reported, and it is estimated that up to 90% of patients with AS harbor the HLAB27
haplotype.
Objective
HLA-B27 is incorporated in the new ASAS classifi cation criteria for diagnosing axial SpA/AS; therefore,
determining the prevalence of HLA-B27 among AS patients in Sulaimani Province could affect the early
recognition and treatment of the disease while preventing undesired complications and preserving the quality
of patients’ lives.
Patients and Methods
This cross-sectional study incorporated ninety-two patients who met the ASAS and mNY criteria for AS. The
patients were visitors of The Rheumatology Centere for Biologic Therapies-Shaheed Hemin Hospital. The
data collection process extended from the 15th of October 2021 to the 20th of April 2022.
Results
Of the total of 92 patients (64 males and 28 females), the prevalence of HLA-B27 was 65.2%. The mean age
of the diagnosis of AS was 32.07 years. The male-to-female ratio of AS was 2.29:1. Meanwhile, the ratio of
males to females with positive HLA-B27 was 2.33:1. The most prevalent symptom was lower back pain in all
the patients comprising 92.4%, followed by enthesitis 40.2%, peripheral arthritis 22.8%, and Uveitis 19.6%.
Conclusion
This study reported the prevalence of HLA-B27 at 65.2% in Sulaimani Province among AS patients. This
fi gure could be dependable in diagnosing and properly treating the disease, particularly in those in the early
stages who have not yet developed radiological evidence of AS.

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  • Published at21 March 2024

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