ASSOCIATION BETWEEN MATERNAL SERUM LIPID PROFILE AT LATE GESTATION WITH NEONATAL MACROSOMIA

Volume 12 , Issue 4 , December 2022 , Pages 449-457

Authors

Salama Kamel Nasir 1 ; Rawaa Mahfoudh Khaleel 1 ; Naz Azad Abdullah 1

1 College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10390

Keywords

Abstract

Background
Macrosomia is a serious health problem that is highly prevalent and can negatively affect neonatal and maternal
outcomes. Pregnant women and neonates can be negatively influenced by dyslipidemia (high maternal serum
lipids) which also results in the development of fetal macrosomia..
Objectives
The current study aimed to determine how maternal lipid profile during the third trimester of pregnancy
correlated with fetal birthweight.
Patients and Methods
A prospective cohort study was conducted in Sulaimani Maternity Teaching Hospital over eight months,
starting from the 1st of September 2018 till the 30th of April 2019. The study included 123 pregnant with a
viable singleton pregnancy, gestational age > 32 weeks, delivered between 37 and 42 weeks of gestational
age, and women suffering from thyroid disorders and hypertension. For all women, total cholesterol (TC),
high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and serum
triglycerides (TG) were measured. In addition, the women were followed up until their childbirth, and the
correlation between the mothers’ lipid profile and their neonates’ weight was measured..
Results
The mean age ± SD (standard deviation) of the studied women was 31.10± 3.65 years, ranging from (25 to 38)
years. Regarding their parity, 78% of women were multiparous (have 2-4 children), and the remaining (22%)
were primipara. Among the 123 participating women, 23 (18.7%) delivered macrosomic babies (weight >
4kg), and 100 (81.3%) delivered babies with normal birth weight. Fifteen women (12.2%) have high cholesterol
levels, and all delivered macrosomic newborns, with a statistically significant association (P=0.001) between
macrosomia and maternal cholesterol level. Also, the prevalence of macrosomia was significantly higher
among women with high serum triglyceride levels (P=0.001).
Conclusion
There is a significant association between increased risk of macrosomia and high serum cholesterol and
triglycerides levels during pregnancy.

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  • Published at21 December 2022

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