CORRELATION OF SERUM FERRITIN, HEMOGLOBIN, AND PLATELET LEVELS IN PREGNANT WOMEN WITH GESTATIONAL DIABETES

Volume 12 , Issue 4 , December 2022 , Pages 395-401

Authors

Sallama Kamel Nasir 1 ; Sara Shakir Mahmood 2 ; Rezan Abdulrahman Ali 3

1 Department of OBS & GYN, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

2 Directory of Health of Sulaimani, Ministry of Health, Kurdistan Region, Iraq.

3 Department of OBS & GYN, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq

DOI logo 10.17656/jsmc.10383

Keywords

Abstract

Background
Gestational diabetes mellitus (GDM) affects approximately 7% of all pregnancies. Pregnancy which is regarded
as a pro-inflammatory state “mostly because of the mitochondria-rich placenta,” is a condition that favors
oxidative stress. A transitional metal, particularly iron, abundant in the placenta, is significant in producing
free radicals. Various studies indicate that free radicals play a remarkable role in GDM. Iron storage and status
in the body can be reliably assessed by serum ferritin as the standard measurement.
Objectives
The present study aimed to measure the serum ferritin level, hemoglobin, and platelet count in women with
GDM and compare it with those of women experiencing a normal pregnancy.
Patients and Methods
This case-control study was conducted in Sulaimani Maternity Teaching Hospital in Sulaimani city, Iraq. Over
18 months, they were starting from Jan 1, 2020, till Jun 30, 2021. The study sample consisted of 160 pregnant
women in the third trimester of their pregnancy. The participating women were divided into a study group
and a control group. The study group consisted of 80 pregnant women with GDM, which OGTT detected
from 24 to 28 weeks of their pregnancy. The control group consisted of 80 pregnant women who had a normal
and healthy pregnancy, did not have GDM, and were in their third trimester. For both groups, mean platelet
volume, platelet count, hemoglobin level, and serum ferritin level were measured, and the two groups were
compared in terms of these variables.
Results
Compared to the control group, the group with GDM had a significantly higher level of mean serum ferritin
(29.04±16.09 ng/ml versus 37.97±29.42 ng/ml) (P=0.02). However, the study and control groups were not
statistically different regarding their mean hemoglobin levels (12.26±0.63g/dl versus 12.14±0.60g/dl)
(P-value=0.19). In addition, the study group had a significantly higher mean platelet count than the control
group (246.71x 103/µl±54.02 versus 203.52 x103/µl±54.1) (P<0.001). However, no significant difference was
seen between the study group and the control group regarding their mean platelet volume (MPV) (9.50±1.25
1015/L versus 9.35±0.95 1015/L) (P=0.41).
Conclusion
Compared with women with normal pregnancy, GDM women have higher serum ferritin levels and platelet
count; therefore, serum ferritin can be regarded as a marker for GDM pathogenesis. However, it is recommended
that serum ferritin levels should be measured in early pregnancy to evaluate the risk of GDM development in
those with high serum ferritin levels.

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  • Published at21 December 2022

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