ENTONOX VERSUS PETHIDINE FOR PAIN RELIEF DURING THE ACTIVE PHASE OF LABOR

Volume 12 , Issue 2 , June 2022 , Pages 125-133

Authors

Shnaw Abdulwahab Karim 1 ; Rozhan Yassin Khalil 2

1 Sulaimani Maternity Teaching Hospital, Sulaimani, Kurdistan Region, Iraq.

2 Sulaimani Maternity Teaching Hospital, College of Medicine,University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10352

Keywords

Abstract

Background
Labour pain is one of the acute severe pains women suffer during their lives. Various methods have been tried
to manage it.
Objectives
The aim was to compare analgesic effects and outcomes of Entonox versus Pethidine for labour pain.
Patients and Methods
The non-blinded Randomised clinical trial was performed on 221 pregnant women admitted to the Labor
Ward of Sulaimani Maternity Teaching Hospital from January 2020 to January 2021. Women were randomly
allocated the group I of 111 pregnant women who received Entonox and group II of 110 pregnant women who
received 1 mg/kg of Pethidine. A visual analogue scale (VAS) pain score was used before 30 and 60 minutes
after drug administration. In addition, a Neonatal Apgar score of one and five minutes was recorded.
Results
There were no significant demographic feature differences between both groups. Mean pain scores before
drugs were 7.8±1.6 and 7.8±1.3 after 30 minutes were 4.6±1.6 and 5.7±1.6, and after 60 minutes were 3.8±1.5
and 3.9±1.6 for Entonox and pethidine groups, respectively. Entonox decreased pain score better than Pethidine
after 30 minutes (p-value of <0.001); however, Pethidine decreased pain score better than Entonox after 60
minutes (p-value of <0.001). Mean Apgar scores in 1st minute were 8.6±.87 and 8.41±1.28, and in 5th minute
was 9.84±.37 and 9.62±.82 for Entonox and pethidine groups, respectively. Significant association of drugs
with Apgar score at 5th minute was found.
Conclusion
Entonox was better for acute pain management within 30 minutes; Pethidine was better for longer than 60
minutes.

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  • Published at21 June 2022

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