THE EFFECT OF TOPICAL STEROID AND ORAL GABAPENTIN IN THE TREATMENT OF CAPECITABINE INDUCE HAND FOOT SYNDROME AMONG CANCER PATIENTS

Volume 11 , Issue 3 , September 2021 , Pages 279-288

Authors

Harez Othman Hassan 1 ; Mohammed Omer Mohammed 2

1 College of Pharmacy, University of Sulaimani, Kurdistan Region, Iraq

2 College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI logo 10.17656/jsmc.10312

Keywords

Abstract

Background
Cancer patients facing many complications during treatments, such as oral Mucositis, neuropathy, and
chemotherapy-induced diarrhoea. Unique toxicities can accompany Specific routes of administration of colon
cancer drugs such as hand-foot syndrome.
Objectives
To study the effects of topical steroids and oral gabapentin in treating capecitabine induce hand-foot syndrome
among cancer patients.
Patients and Methods
A total of 50 patients diagnosed with hand-foot syndrome attended in Hiwa cancer hospital in Sulaimani-Iraq,
who met the inclusion criteria, were enrolled in the current study from august 2019-February 2020. patient’s
characteristics, concomitant drugs Used, any other diseases were recorded in a questionnaire designed for
the study. Grading of the hand-foot syndrome and its severity of presentation is done by Using NCI-CTCAE
(National Cancer Institute - Common Terminology Criteria for Adverse Events) and WHO (World Health
Organization) and associated histologic findings. In addition, the quality of Life of the Patients was evaluated
by using RAND 36-item short forming survey (SF36); The DN4 scale measured the neuropathy of Patients.
Results
The grades of the hand-foot syndrome after treatment were significantly improved compared to pretreatment
(p-value; ≥0.001). Moreover, it changed the frequency of hand-foot syndrome by using topical steroids
(clobetasol 0.05%), gabapentin, or both.
Conclusion
The study showed a statistically significant improvement in grades of the hand-foot syndrome of participants
and increasing quality of life through using topical Steroids and gabapentin.

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  • Published at21 September 2021

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