THE RELATION BETWEEN MRI CHANGES, CALCITONIN GENE-RELATED PEPTIDE AND BLOOD LIPID IN MIGRAINE PATIENTS

Volume 11 , Issue 3 , September 2021 , Pages 263-272

Authors

Anmar Ahmed Ali 1 ; Nazaneen Akbar Omer 2 ; Zana A. Mohammed 3 ; Sarwer Jamal Al-Bajalan 3

1 Department of Neurology, Shar Teaching Hospital, Sulaimani, Iraq.

2 Department of Medical Biochemistry, College of Medicine, University of Sulaimani, Sulaimani, Iraq.

3 Department of Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq.

DOI logo 10.17656/jsmc.10310

Keywords

Abstract

Background
Vascular-neuronal systems are highly affected by lipid levels, and migraine, associated with calcitonin generelated
peptide (CGRP) changes. Therefore, magnetic resonance imaging (MRI) has recently been employed
to evaluate headaches in patients with migraines
Objectives
This study investigates the relationship between MRI changes and blood lipid and CGRP levels in migraineurs
Materials and Methods
This case-control study was carried out on 93 patients with migraines and 30 healthy individuals in Shar
Teaching Hospital from Oct. 2018 to Oct. 2019. Detailed history and clinical examination were conducted for
all of the participants. Data including weight, height, body mass index (BMI), fasting blood glucose (FBG),
lipid profile, and CGRP levels were collected. In addition, MRI was performed for all of the participants.
Results
The mean age of the patients was 33 years; 86% of them were females. Brain MRI lesions were detected in
22 (23.7%) of the patients vs 2 (6.7%) of the controls with significant differences (p=0.04). The lesions were
observed on fluid-attenuated inversion recovery (FLAIR) in 21(22.6%) or T2 in 6 (6.5%). No lesions were
detected on T1 or diffusion-weighted images (DWI). There were no significant relationships between the
MRI findings and the CGRP, lipid profile, FBG, or vitamin-D3 levels of the patients (p>0.05). Moreover, the
patients and controls were comparable in their lipid profile, FBG, vitamin-D3, or CGRP levels (p>0.05).
Conclusion
Although MRI lesions were detected in a significant proportion of migraine patients, these findings were not
significantly related to changes in CGRP and lipid profile levels.
Keywords: Migraine, Lipid profile, Calcitonin gene-related peptide

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