ROLE OF FECAL CALPROTECTIN IN DIFFERENTIATION OF INFLAMMATORY BOWEL DISEASES IN PATIENTS COMPLAINING OF ABDOMINAL SYMPTOMS AND REFERRED FOR COLONOSCOPY

Volume 11 , Issue 1 , March 2021 , Pages 34-44

Authors

Trifa A. Mahmood 1 ; Mohammed O. Mohammed 2 ; Dana T. Gharib 2 ; Taha A. Mohamad 2 ; Muhsin A. Mohammed 2 ; Araz L. Rahim 2

1 College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

2 Kurdistan Centre of Gastroenterology and Hepatology (KCGH), Sulaymaniyah, Kurdistan Region, Iraq.

DOI logo 10.17656/Jsmc.10285

Keywords

Abstract

Background 

The difficulty in differentiating functional gastrointestinal disorders and inflammatory bowel diseases in patients presenting with abdominal symptoms direct us to the use of fecal inflammatory biomarkers that are specific to intestinal inflammation.

Objectives 

To assess the benefits of fecal calprotectin (FC) in patients presenting with lower abdominal symptoms. Also, correlating the FC and CRP titer with abdominal pain severity.

Patients and Methods

Prospective cross-sectional study in Kurdistan Center for Gastroenterology and Hepatology (KCGH), Sulaimaniyah city, Northern Iraq. A total of 174 patients with IBS according to Rome IV criteria, who visited KCGH, met the inclusion criteria. FC titer measured before colonoscopy appointment, abdominal pain severity scored according to visual scale, and colonoscopy performed by a specialized gastroenterologist. 

Results

The FC level was below 50ug/g for 91.3% of patients with normal endoscopy; all of the IBD cases had FC level above 100ug/g. Seven of the eight patients with non-inflamed polyp or diverticuli had an FC level of less than 50ug/g. Moreover, in this study, the CRP level is also significantly higher among IBD cases than in patients with normal colonoscopy. 

Conclusion

FC titer is a useful measure before the decision for colonoscopy especially in cases not having alarm symptoms and other comorbidities. FC and CRP level is associated with the severity of abdominal pain.

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  • Published at21 March 2021

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