• Anmar Ahmed Ali Department of Neurology, Shar Teaching Hospital, Sulaimani, Kurdistan Region, Iraq.
  • Nazaneen Akbar Omer Department of Medical Biochemistry, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Zana A. Mohammed Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Sarwer Jamal Al-Bajalan Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.



Migraine, Lipid profile, Calcitonin gene-related peptide (CGRP)



Vascular-neuronal systems are highly affected by lipid levels, and migraine, associated with calcitonin gene-related peptide (CGRP) changes. Therefore, magnetic resonance imaging (MRI) has recently been employed to evaluate headaches in patients with migraines.


This study investigates the relationship between MRI changes and blood lipid and CGRP levels in migraineurs

Materials and Methods

This case-control study was carried out on 93 patients with migraines and 30 healthy individuals in Shar Teaching Hospital from Oct. 2018 to Oct. 2019. Detailed history and clinical examination were conducted for all of the participants. Data including weight, height, body mass index (BMI), fasting blood glucose (FBG), lipid profile, and CGRP levels were collected. In addition, MRI was performed for all of the participants.


The mean age of the patients was 33 years; 86% of them were females. Brain MRI lesions were detected in 22 (23.7%) of the patients vs 2 (6.7%) of the controls with significant differences (p=0.04). The lesions were observed on fluid-attenuated inversion recovery (FLAIR) in 21 (22.6%) or T2 in 6(6.5%). No lesions were detected on T1 or diffusion-weighted images (DWI). There were no significant relationships between the MRI findings and the CGRP, lipid profile, FBG, or vitamin-D3 levels of the patients (p>0.05). Moreover, the patients and controls were comparable in their lipid profile, FBG, vitamin-D3, or CGRP levels (p>0.05).


Although MRI lesions were detected in a significant proportion of migraine patients, these findings were not significantly related to changes in CGRP and lipid profile levels.


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How to Cite

Ali A, Omer N, Mohammed Z, Al-Bajalan S. THE RELATION BETWEEN MRI CHANGES, CALCITONIN GENE-RELATED PEPTIDE AND BLOOD LIPID IN MIGRAINE PATIENTS. JSMC [Internet]. 2021 Sep. 21 [cited 2024 May 28];11(3):263-72. Available from:

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