RISK FACTORS OF COLORECTAL CANCER IN SULAIMANI CITY
Mohammed Abdalwahab Hassan a, Kameran H. Ismail b, Zhian S. Ramzi c, and Tariq S. Al-Hadithi b
a Directorate of Health, Sulaimani city
b College of Medicine, Hawler Medical University
c College of Medicine, Sulaimani University
Submitted: 19/6/2017; Accepted: 7/2/2018; Published 15/4/2018
DOI Link: https://doi.org/10.17656/jsmc.10150
The risk of developing colorectal cancer is influenced by both environmental and genetic factors. Globally, colorectal cancer is the third most commonly diagnosed cancer in males and the second in females.
This study was conducted to determine the risk factors of colorectal cancer in a sample of colorectal cancer patients in Sulaimani city.
A case-control study was carried out between December, 2014 and March, 2016. The cases were interviewed in Hewa hospital in Sulaimani city, which is the only health institution dealing with cancer patients in the city. A sample of 200 cases whom diagnosed and registered at the hospital was selected. Those cases were compared with 400 controls free from cancer matched in age (± 2 years) and gender. Controls were collected from patients attending Karezawshk and Xabat public clinics.
Patients with colorectal cancer have a mean ± SD age of 53.85 ± 15.9 years (ranged from 18 to 90 years) and the controls have a mean ± SD age of 53.69 ± 13.7 years (ranged from 19 to 87 years). Male: female ratio was 1.1:1. Logistic regression analysis revealed that there are positive statistical significant associations of colorectal cancer with family history of CRC (OR=8.489, 95% CI=3.285-21.941), smoking (OR=3.392, 95% CI=1.774-6.485), overweight and obesity (OR=6.034, 95% CI=3.386-10.755), drinking of carbonated beverages (OR=5.822, 95% CI=3.286-10.314) and canned juice (OR=3.448, 95% CI=1.972-6.028). However, negative statistical significant association between colorectal cancer and practicing exercise (OR=0.535, 95% CI= 0.290-0.987) and drinking of fresh juice (OR=0.283, 95% CI=0.163-0.491) was detected.
The most common risk factors for colorectal cancer are family history of colorectal cancer, smoking, overweight, obesity, drinking of carbonated beverages, and canned juice, while practicing exercise and drinking of fresh juice are decreasing the risk for colorectal cancer.
Colorectal cancer, Risk factor, Sulaimania, Iraq.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61(2):69-90.
Singh KE, Taylor TH, Pan CG, Stamos MJ, Zell JA. Colorectal cancer incidence among young adults in California. J Adolesc Young Adult Oncol 2014; 3(4):176-84.
Tawadros PS, Paquette IM, Hanly AM, Mellgren AF, Rothenberger DA, Madoff RD. Adenocarcinoma of the rectum in patients under age 40 is increasing: impact of signet-ring cell histology. Dis Colon Rectum 2015; 58(5):474-8.
Lee BY, Sonnenberg A. Time trends of mortality from colorectal cancer in the United States: a birth-cohort analysis. JAMA Intern Med 2013; 173(12):1148-50.
Hanlon P, Byers M, Walker BR, Summerton C. Nutrition, metabolic and environmental disease. In: Boon AN, Colledge RN, Walker RB, editors. Davidson’s principles and practice of medicine. 20th ed. Edinburgh: Churchill Livingstone; 2010
Davis DM, Marcet JE, Frattini JC, Prather AD, Mateka JJ, Nfonsam VN. Is it time to lower the recommended screening age for colorectal cancer? J Am Coll Surg 2011; 213(3):352-61.
Doubeni CA, Laiyemo AO, Major JM, Schootman M, Lian M, Park Y, et al. Socioeconomic status and the risk of colorectal cancer: an analysis of more than a half million adults in the National Institutes of Health-AARP Diet and Health Study. Cancer 2012; 118(14):3636-44.
Ward HA, Norat T, Overvad K, Dahm CC, Bueno-de-Mesquita HB, Jenab M, et al. Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition. Br J Nutr 2016; 116(2):316-25.
Borras E, San Lucas FA, Chang K, Zhou R, Masand G, Fowler J, et al. Genomic landscape of colorectal mucosa and adenomas. Cancer Prev Res 2016; 9(6):417-27.
Schoen RE, Razzak A, Yu KJ, Berndt SI, Firl K, Riley TL, et al. Incidence and mortality of colorectal cancer in individuals with a family history of colorectal cancer. Gastroenterology 2015; 149(6):1438-45 e1.
Dominianni C, Huang WY, Berndt S, Hayes RB, Ahn J. Prospective study of the relationship between coffee and tea with colorectal cancer risk: the PLCO cancer screening trial. Br J Cancer 2013; 109(5):1352-9.
Hibler E. Epigenetics and colorectal neoplasia: the evidence for physical activity and sedentary behavior. Curr Colorectal Cancer Rep 2015; 11(6):388-96.
Arem H, Mayne ST, Sampson J, Risch H, Stolzenberg-Solomon RZ. Dietary fat intake and risk of pancreatic cancer in the prostate, lung, colorectal and ovarian cancer screening trial. Ann Epidemiol 2013; 23(9):571-5.
Troche JR, Mayne ST, Freedman ND, Shebl FM, Guertin KA, Cross AJ, et al. Alcohol consumption-related metabolites in relation to colorectal cancer and adenoma: two case-control studies using serum biomarkers. PLoS One 2016; 11(3):e0150962.
Walter V, Jansen L, Ulrich A, Roth W, Blaker H, Chang-Claude J, et al. Alcohol consumption and survival of colorectal cancer patients: a population-based study from Germany. Am J Clin Nutr 2016; 103(6):1497-506.
Azeem K, Sevcikova J, Kysely Z, Horakova D, Vlckova J, Kollarova H. Primary and secondary prevention of colorectal cancer in the Czech Republic. Prz Gastroenterol 2016; 11(1):1-5.
Kitahara CM, Berndt SI, de Gonzalez AB, Coleman HG, Schoen RE, Hayes RB, et al. Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. J Clin Oncol 2013; 31(19):2450-9.
Lee SH, Hong JY, Lee JU, Lee DR. Association between exposure to environmental tobacco smoke at the workplace and risk for developing a colorectal adenoma: a cross-sectional study. Ann Coloproctol 2016; 32(2):51-7.
Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, et al. Meat, fish, and colorectal cancer risk: the European prospective investigation into cancer and nutrition. J Natl Cancer Inst 2005; 97(12):906-16.
Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, Korakakis E, et al. Associations between dietary and lifestyle risk factors and colorectal cancer in the Scottish population. Eur J Cancer Prev 2014; 23(1):8-17.
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