EFFECT OF AGE, GENDER, BLOOD GROUP AND SOCIAL STATE ON THE SERO-PREVALENCE OF HELICOBACTER PYLORI INFECTION AMONG ASYMPTOMATIC SUBJECTS IN SULAIMANI
Hadeel Abdul Elah Ibrahim *, Hawa A. R. Al-Dhahir ** and Mohammed Omer Mohammed ***
* College of Nursing, University of Sulaimani.
** Department of Physiology, College of Medicine, University of Baghdad.
*** Department of Medicine, School of Medicine, Faculty of Medical Sciences, University of Sulaimani.
Submitted: 25/5/2014; Accepted: 12/8/2014; Published 1/6/2015
DOI Link: https://doi.org/10.17656/jsmc.10066
It is known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. Infections due to H. pylori are most widespread among the developing regions due to poor standard of public health.
This study sought to determine the seroprevalence of H. pylori in asymptomatic individual in Sulaimani and to correlate such prevalence with age, gender, blood group and Socioeconomic state.
This study conducted in Ali Kamal Consultation clinic, Kurdistan Teaching center of Gastroenterology & Hepatology (escorts of patients) and students from University of Sulaimani, from the 1st of January to the 20th of November 2013. Serum samples from 188 apparently healthy subjects were tested for the presence of IgG and IgA antibody to H. pylori by use of ELISA test. ABO blood grouping was also done by hemagglutination
Of the 188 subjects, there were 92(48.9%) males and 96 (51.1%) females. The age range was 20 to 49 years. The overall prevalence of H. pylori infection in our study was 68.1%. H. pylori antibodies were positive in 73(79.4%) males and 55(57.3%) females, showing no significant difference P=0.079. The overall seroprevalence was found in 57.1% subjects between 20-29 years of age, 75.8% in subjects between 40-49 years of age showing significant difference P=0.045. Distribution of ABO blood groups in H. pylori positive group were, A=70.2%, B=32.4%, AB=57.1% and O=86.1%, with a statistically significant link for blood group O (p=0.001). H. pylori sero-positivity was higher in low social state 59(93.7%), moderate social state 47(87%) then lowest in high social state 22 (31%), P = 0.032.
This study demonstrated that H. pylori infection can be related to ABO blood group, age and social state. People of blood group O, 40-49 years of age and low social state are more prone to develop this infection.
H. pylori- Gender- Age- Blood group - Socioeconomic state, Sulaimani.
Jing C, Huang ZJ, Duan YQ, Wang PH, Zhang R, Luo KS, et al. Glulathione-s-transferases gene polymorphism in prediction of gastric cancer risk by smoking and Helicobacter pylori infection status. Asian Pac J Cancer Prev 2012; 13, 3325-8.
Kirchner GI, Beil W, Bleck JS, Manns MP, Wagner S. Prevalence of Helicobacter pylori and occurrence of gastroduodenal lesions in patients with liver cirrhosis. Int J ClinExp Med 2011; 4(1): 26–31.
Al-Akwaa AM. Prevalence of Helicobacter pylori infection in a group of morbidly obese Saudi patients undergoing bariatric surgery: A preliminary report. Saudi J Gastroenterol 2010; 16(4). 264–267.
Kanbay M, Gur G, Arslan H, Yilmaz U, Boyacioglu S. The relationship of ABO blood group, age, gender, smoking, and Helicobacter pylori infection. Dig Dis Sci 2005; 50, 1214-7.
Wu TC, Chen LK, Hwang SJ. Seroprevalence of Helicobacter pylori in school-aged Chinese in Taipei City and relationship between ABO blood groups. World J Gastroenterol 2003; 9, 1752-5.
Kindermann A, Lopes AI. Review Helicobacter pylori infection in pediatrics. Helicobacter 2009; 14(Suppl): 52-57.
Bastos J, Peleteiro B, Pinto H, Marinho A, Guimarães JT, Ramos E, et al. Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen). Dig Liver Dis 2013; 45(4):290-5.
Karczewska E, Klesiewicz K, Skiba I, Wojtas-Bonior I, Sito E, Czajecki K, et al. Variability in prevalence of Helicobacter pylori strains resistant to clarithromycin and levofloxacin in Southern Poland. Gastroenterol Res Pract 2012; doi: 10.1155/2012/418010.
Sasidharan S, Ghayethry B, Ravichandran M, Latha LY, Lachumy SJ, Leng KM. Prevalence of Helicobacter pylori infection among patients referred for endoscopy: Gender and ethnic differences in Kedah, Malaysia. Asian Pac J Trop Dis 2012; 2(1): 55-59.
Stasi R, Provan D. Helicobacter pylori and Chronic ITP. Hematology Am Soc Hematol Educ Program 2008; 206-211.
Nurgalieva ZZ, Malaty HM, Graham DY, Almuchambetova R, Machmudovaet A, Kapsultanova D, et al. Helicobacter pylori infection in Kazakistan: effect of water source and household hygiene. Am J Trop Med Hyg 2002; 67: 201-206.
Zhou Y, Xu L, Wang B, Fan X, Wu J, Wang C, et al. Modified sequential therapy regimen versus conventional triple therapy for Helicobacter pylori eradication in duodenal ulcer patients in China: A multicenter clinical comparative. Gastroenterol Res Pract 2012; doi: 10.1155/2012/405425.
Lane JA, Murray LJ, Sian N, Egger M, Harvey IM, Donovan JL, et al. Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial. BMJ 2006; 332(7535): 199–204.
Martins LC, de Oliveira Corvelo TC, Oti HT, do Socorro Pompeu Loiola R, Aguiar DC, dos Santos Barile KA, et al. ABH and Lewis antigen distributions in blood, saliva and gastric mucosa and H pylori infection in gastric ulcer patients. World J Gastroenterol 2006; 12, 1120-4.
Kumar N, Shekhar C, Kumar P and Kundu A.S. Kuppuswamy’s Socioeconomic Status Scale-Updating for 2007. Indian J Pediatr 2007; 74:1131-2.
Vengelen-TylerV. (1996). Technical manual, 12th ed. American Association of blood Banks.
Newell DG, Johnston BJ, Ali MH, Reed PI. An enzyme linked immunosorbent assay for the serodiagnosis of Campylobacter pylori-associated gastritis. Scand J Gastroenterol 1988; 23 (suppl 142): 53-7.
Al-Balushi MS , Al-Busaidi J Z, Al-Daihani MS, Shafeeq MO, Hasson SS. Sero-prevalence of Helicobacter pylori infection among asymptomatic healthy Omani blood donors. Asian Pac J Trop Dis 2013; 3(2): 146-1492013 .
Bakka AS, El-Gariani AB, AbouGhrara FM, Salih BA. Frequency of Helicobacter pylori infection in dyspeptic patients in Libya. Saudi Med J 2002; 23(10): 1261-1265.
Moges F, Kassu A, Mengistu G, Adugna S, Andualem B, Nishikawa T, et al. Seroprevalence of Helicobacter pylori in dyspeptic patients and its relationship with HIV infection, ABO blood groups and life style in a university hospital, northwest Ethiopia. World J Gastroenterol 2006; 12(12): 1957-1961.
Newton R, Ziegle JL, Carpenter L, Gold BD, Owens M, Beral V, et al. Helicobacter pylori and cancer among adults in Uganda. Infect Agent Cancer 2006; 1: 5.
Smith JG, Li W, Rosson RS. Prevalence, clinical and endoscopic predictors of Helicobacter pylori infection in an urban population. Conn Med 2009; 73: 133-137.
Moayyed P, Axon AT, Feltbower R, Duffett S, Crocombe W, Braunholtz D, et al. Relation of adult lifestyle and socioeconomic factors to the prevalence of Helicobacter pylori infection. Int J Epidemiol 2002; 31: 624-631.
Bhat N., Gaensbauer J, Peek RM, Bloch K, Tham K T, Blaser M J, et al. Local and systemic immune and inflammatory responses to Helicobacter pylori strains. Clin Diagn Lab Immunol 2005; 12, 1393-400.
Lenzi C, Palazzuoli A, Giordano N, Alegente G, Gonnelli C, Campagna MS,et al., H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease. World J Gastroenterol 2006 December 28; 12(48): 7815-7820.
Valliani A, Khan F, Chagani B, Khuwaja A, Majid S, Hashmi S, et al Factors Associated with Helicobacter Pylori Infection, Results from a Developing Country Pakistan. Asian Pacific J Cancer Prev 2013; 14 (1), 53-56.
Us D, Hascelik G. Seroprevalence of Helicobacter pylori infection in an asymptomatic Turkish population. J Infect 1998; 37: 148-150.
Pilotto A, Franceschi M. Helicobacter pylori infection in older people. World J Gastroenterol. 2014 June 7; 20(21): 6364-6373.
Alkout AM, Blackwell CC, Weir DM. Increased inflammatory responses of persons of blood groups O to Helicobacter pylori. J Infect Dis 2000; 181, 1364-9.
Bhuiyan TR, Qadri F, Saha A, Svennerholm AM. Infection by Helicobacter pylori in Bangladeshi children from birth to two years: relation to blood group, nutritional status, and seasonality. Pediatr Infect Dis J 2009; 28, 79-85.
Jafarzadeh A, Ahmedi-Kahanali J, Bahrami M, Taghipour Z. Seroprevalence of anti-Helicobacter pylori and anti-CagA antibodies among healthy children according to age, sex, ABO blood groups and Rh status in south-east of Iran. Turk J Gastroenterol 2007; 18, 165-71.
Mandell GL, Bennnett JE, Dolin R.: Mandell , Douglas and Bennnett’s principles and practice of infectious disease 6th ed. Elsevier Inc.2010; vol.2 p 2803-2813.
Kivi M, Tindberg Y. Helicobacter pylori occurrence and transmission: A family affair? Scand. J Infect Dis 2006; 38:407-17.
Feldman M, Friedman LS, Brandt LJ. Epidemiology of Helicobacter pylori. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease Pathophysiology/Diagnosis/Management. Peura DA and Crowe SE.(Eds.), (Ninth edition). Saunders company, Philabilphia - Canada 2010; p:833-834.
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