THE EFFECT OF TOPICAL STEROID AND ORAL GABAPENTIN IN THE TREATMENT OF CAPECITABINE INDUCE HAND FOOT SYNDROME AMONG CANCER PATIENTS
Harez Othman Hassan a and Mohammed Omer Mohammed b
a College of Pharmacy, University of Sulaimani, Kurdistan Region, Iraq.
b College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
Submitted: 14/9/2020; Accepted: 3/2/2021; Published: 21/9/2021
DOI Link: https://doi.org/10.17656/jsmc.10312
Cancer patients facing many complications during treatments, such as oral Mucositis, neuropathy, and chemotherapy-induced diarrhoea. Unique toxicities can accompany Specific routes of administration of colon cancer drugs such as hand-foot syndrome.
To study the effects of topical steroids and oral gabapentin in treating capecitabine induce hand-foot syndrome among cancer patients.
Patients and Methods
A total of 50 patients diagnosed with hand-foot syndrome attended in Hiwa cancer hospital in Sulaimani-Iraq, who met the inclusion criteria, were enrolled in the current study from august 2019-February 2020. patient’s characteristics, concomitant drugs Used, any other diseases were recorded in a questionnaire designed for the study. Grading of the hand-foot syndrome and its severity of presentation is done by Using NCI-CTCAE (National Cancer Institute - Common Terminology Criteria for Adverse Events) and WHO (World Health Organization) and associated histologic findings. In addition, the quality of Life of the Patients was evaluated by using RAND 36-item short forming survey (SF36); The DN4 scale measured the neuropathy of Patients.
The grades of the hand-foot syndrome after treatment were significantly improved compared to pretreatment (p-value; ≥0.001). Moreover, it changed the frequency of hand-foot syndrome by using topical steroids (clobetasol 0.05%), gabapentin, or both.
The study showed a statistically significant improvement in grades of the hand-foot syndrome of participants and increasing quality of life through using topical Steroids and gabapentin.
Capecitabine, Hand-foot syndrome, Clobetasol, gabapentin, Quality of life SF36.
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