MYELOID SARCOMA PRESENTING AS SKIN NODULES IN SULAYMANIYAH CITY

Authors

  • Kani Delawer Department of Hematopathology, Hiwa Cancer Hospital, Ministry of Health, Kurdistan Region, Iraq.
  • Hisham Arif Getta Department of Pathology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Dana N. Muheadeen Department of Pathology, Shorsh General Hospital, Hiwa Cancer Hospital, Ministry of Health, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.17656/jsmc.10443

Keywords:

Myeloid sarcoma, Skin nodule, AML

Abstract

Myeloid sarcoma is a rare malignant myeloid tumour known as granulocytic sarcoma or chloroma. As not all myeloid leukaemias are derived from granulocytes, the preferred term is myeloid sarcoma instead of granulocytic sarcoma and chloroma, consisting of the myeloid blast with or without maturation. Myeloid sarcoma may occur de novo or precede or be associated with acute or chronic myeloid leukaemias, or represent a blast transformation of myeloproliferative disorders, myelodysplastic syndromes, or it may represent a relapsed state in patients diagnosed previously as AML regardless of blood or BM findings. It is more common in adults between 45 and 55 years of age. Myeloid sarcoma can involve any body site other than the bone marrow that totally or partially effaced the tissue architecture. The most affected sites are lymph nodes, skin, and bones (1). Skin, soft tissues, bone, lymph nodes, GIT, and testis are common sites to be involved (2). Occurrence in the other sites like skull bones, orbit, and paranasal sinuses is unusual (3). The pathogenesis of this sarcoma is believed to be an aberrant expression of homing signals for the leukemic blasts
on extramedullary sites compared to bone marrow.

References

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Kitagawa Y, Sameshima Y, Shiozaki H, Ogawa S, Masuda A, Mori SI, et al. Isolated granulocytic sarcoma of the small intestine was successfully treated with chemotherapy and bone marrow transplantation. Int J Hematol. 2008; 87(4):410–3.

Pileri SA, Orazi A, Falini B. Myeloid sarcoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: International Agency for Research on Cancer;

P. 140-1.

Published

2023-12-21

How to Cite

1.
Delawer K, Getta H, Muheadeen D. MYELOID SARCOMA PRESENTING AS SKIN NODULES IN SULAYMANIYAH CITY. JSMC [Internet]. 2023 Dec. 21 [cited 2024 Jul. 15];13(4):4. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10443

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