THE RELATIONSHIP BETWEEN VITAMIN D3 LEVELS AND HYPOTHYROIDISM

Authors

  • Dilshad Hamad Mustafa College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
  • Ribwar Arsalan Mohammed College of Nursing, University of Raparin, Kurdistan Region, Iraq.
  • Aveen Muhsin Asaad Koya Technical Institute, Erbil Polytechnic University, Kurdistan Region, Iraq.
  • Dawan Jamal Hawezy College of Medicine, Koya University, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.17656/jsmc.10355

Keywords:

Relationship, Vitamin D3, Hypothyroidism

Abstract

Background 

It has been well observed that vitamin D deficiency may increase the prevalence of hypothyroidism. However, there is little information on the relationship between vitamin D levels and thyroid diseases amongst the Kurdish population.

Objectives 

To find an association between thyroid function parameters and levels of Vit. D among two different groups.

Patients and Methods

A case-control study was employed; two groups participated in the study, the first group was healthy individuals, and the other group was those with hypothyroidism.

Results

The results of 90 persons were collected in the recent study. The mean age was 42.76 ± 9.47. The majority of the participants were women (52.2%). Vitamin D levels were deficient in most participants (50%), which means lower than 20.1 ng/ ml. Only about 37% of the participants had an average level of Vit. D. 

Conclusion

Deficiency in Vitamin D3 is significantly associated with all thyroid function parameters.

References

Mazahery H, von Hurst PR. Factors affecting 25-hydroxyvitamin D concentration in response to vitamin D supplementation. Nutrients. 2015;7(7):5111–42. DOI: https://doi.org/10.3390/nu7075111

Tiwari P, Sharma N. Role of Vitamin D in Various Illnesses: A Review. J Pharm Care Heal Syst. 2017;04(03). DOI: https://doi.org/10.4172/2376-0419.1000176

Peterlik M, Cross HS. Vitamin D and calcium deficits predispose to multiple chronic diseases. Eur J Clin Invest [Internet]. 2005 May 1;35(5):290–304. Available from: https://doi.org/10.1111/j.1365-2362.2005.01487.x DOI: https://doi.org/10.1111/j.1365-2362.2005.01487.x

Nam GE, Kim DH, Cho KH, Park YG, Do Han K, Kim SM, et al. 25-Hydroxyvitamin D insufficiency is associated with cardiometabolic risk in Korean adolescents: the 2008–2009 Korea National Health and Nutrition Examination Survey (KNHANES). Public Health Nutr. 2014;17(1):186–94. DOI: https://doi.org/10.1017/S1368980012004855

Martins JS, Palhares MDO, Teixeira OCM, Gontijo Ramos M. Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians. J Nutr Metab. 2017;2017. DOI: https://doi.org/10.1155/2017/9056470

Kelishadi R. Childhood overweight, obesity, and metabolic syndrome in developing countries. Epidemiol Rev. 2007;29(1):62–76. DOI: https://doi.org/10.1093/epirev/mxm003

Klecha AJ, Arcos MLB, Frick L, Genaro AM, Cremaschi G. Immune-endocrine interactions in autoimmune thyroid diseases. Neuroimmunomodulation. 2008;15(1):68–75. DOI: https://doi.org/10.1159/000135626

Hantoosh HA, Mahdi MH, Imran BW, Yahya AA. Prevalence of Vitamin D deficiency in Iraqi females at reproductive age. Med J Babylon. 2019;16(2):119. DOI: https://doi.org/10.4103/MJBL.MJBL_9_19

Al-Alyani H, Al-Turki HA, Al-Essa ON, Alani FM, Sadat-Ali M. Vitamin D deficiency in Saudi Arabians: a reality or simply hype: a meta-analysis (2008–2015). J Family Community Med. 2018;25(1):1. DOI: https://doi.org/10.4103/jfcm.JFCM_73_17

Castellano C-A, Laurin D, Langlois M-F, Fortier M, Tessier D, Gaudreau P, et al. Thyroid function and cognition in the euthyroid elderly: A case-control study embedded in Quebec longitudinal study–NuAge. Psychoneuroendocrinology. 2013;38(9):1772–6. DOI: https://doi.org/10.1016/j.psyneuen.2013.02.013

Niafar M, Pourafkari L, Aminmozaffari S, Nader ND. Association of vitamin D deficiency and thyroid function in postmenopausal women. Adv Pharm Bull. 2016;6(4):639. DOI: https://doi.org/10.15171/apb.2016.078

Mackawy AMH, Al-Ayed BM, Al-Rashidi BM. Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim). 2013;7(3):267. DOI: https://doi.org/10.12816/0006054

Jyotsna VP, Sahoo A, Singh AK, Sreenivas V, Gupta N. Bone mineral density in patients of Graves disease pre-& post-treatment in a predominantly vitamin D deficient population. Indian J Med Res. 2012;135(1):36. DOI: https://doi.org/10.4103/0971-5916.93422

Effraimidis G, Badenhoop K, Tijssen JGP, Wiersinga WM. Vitamin D deficiency is not associated with the early stages of thyroid autoimmunity. Eur J Endocrinol. 2012;167(1):43. DOI: https://doi.org/10.1530/EJE-12-0048

Simsek Y, Cakır I, Yetmis M, Dizdar OS, Baspinar O, Gokay F. Effects of Vitamin D treatment on thyroid autoimmunity. J Res Med Sci Off J Isfahan Univ Med Sci. 2016;21. DOI: https://doi.org/10.4103/1735-1995.192501

Smith MA, McHenry C, Oslapas R, Hofmann C, Hessel P, Paloyan E. Altered TSH levels associated with increased serum 1, 25-dihydroxy vitamin D3: a possible link between thyroid and parathyroid disease. Surgery. 1989;106(6):987–91.

GROSS HA, APPLEMAN JR MD, NICOLOFF JT. Effect of biologically active steroids on thyroid function in man. J Clin Endocrinol Metab. 1971;33(2):242–8. DOI: https://doi.org/10.1210/jcem-33-2-242

Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is essential in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000;141(4):1317–24. DOI: https://doi.org/10.1210/endo.141.4.7403

Barchetta I, Baroni MG, Leonetti F, De Bernardinis M, Bertoccini L, Fontana M, et al. TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults. Clin Exp Med. 2015;15(3):389–96. DOI: https://doi.org/10.1007/s10238-014-0290-9

Wang J, Lv S, Chen G, Gao C, He J, Zhong H, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 2015;7(4):2485–98. DOI: https://doi.org/10.3390/nu7042485

Published

2022-06-21

How to Cite

1.
Mustafa D, Mohammed R, Asaad A, Hawezy D. THE RELATIONSHIP BETWEEN VITAMIN D3 LEVELS AND HYPOTHYROIDISM. JSMC [Internet]. 2022 Jun. 21 [cited 2024 Jul. 13];12(2):151-6. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10355

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