EPIDEMIOLOGIC AND PATHOLOGIC CHARACTERISTICS OF PATIENTS WITH ESOPHAGEAL CARCINOMA AT KURDISTAN CENTER FOR GASTROENTEROLOGY AND HEPATOLOGY

Authors

  • Abdullah S. Ibrahim Department of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
  • Rebaz Lake Faculty of Medical Specialties, Kurdistan Board for Medical specialties, Erbil, Kurdistan Region, Iraq.
  • Karokh H. Salih Department of Pathology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Mohammed O. Mohammed Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.17656/jsmc.10198

Keywords:

Esophageal carcinoma, Epidemiology, KCGH, Sulaimani

Abstract

Background 

Esophageal carcinoma is the sixth in cancer incidence and cancer related deaths. There are marked geographic variations in the incidence of different types and etiology/risk factors for esophageal carcinoma. Better understanding of the etiology/ risk factors may suggest opportunity for its primary prevention. 

Objectives 

To assess the demographic characteristics, etiology and risk factors of patients with esophageal carcinoma at Kurdistan Center for Gastroenterology and Hepatology.

Materials and Methods

A cross sectional study extended from March 2014 to December 2015; during this period100 patients with histologically diagnosed as esophageal carcinoma (EC) were included. Details about the demographic characteristics and risk factors for esophageal carcinoma had been reviewed.

Results

The mean age of the study population was 67±13.27 years. The male constituted 58% and female 42%, (75%) were Squamous cell carcinoma (SCC) and (25%) were Adenocarcinoma (AC). Up to 84% of AC cases were male (P value: 0.002). There was significant association beteewn type of esophageal cancer and tea drinking, temperature of tea and interval between tea being poured and drunken, P- value was 0.011, 0.031 and 0.001 respectively. There was no statistically significant association between types of EC and demographic characteristic, smoking and body mass index.

Conclusion

SCC was more common than AC; AC was more common in males. Drinking hot tea was associated with EC. Most patients were smoker and had low fruit and vegetable intake, with more dried and preserved foods intake.

References

- Helena Kollarova, Lucie Machova, Dagmar Horakova, Gabriela Janoutova, Vladimir Janout. Epidemiology of Esophageal Cancer – An Overview Article. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2007; 151(1):17–28. DOI: https://doi.org/10.5507/bp.2007.003

- Neal C. Patel, Francisco C. Ramirez. Esophageal Tumors. In: Feldman M, Friedman LS, Brandt LJ Editors. Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology, diagnosis, management. 10th ed. Saunders: Elsevier; 2015, P. 773-790.

- Mate Knabe, Christian Kurz, Thorsten Knoll, Thomas Velten, Michael Vieth, Hendrik Manner, et al. Diagnosing early Barrett’s neoplasia and esophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue. United European Gastroenterology Journal 2013; 1(4): 236–241. DOI: https://doi.org/10.1177/2050640613495198

-Intisar M. Jumaa , Saad H. Mohammed Ali ,Tural Y. Bakir , Delaram M. Ardalan. Molecular Detection and Genotyping of Human Papilloma VirusInfections in Iraqi Patients with Esophageal Carcinoma. J Fac Med Baghdad 2009 ;Vol. 51:No. 2.

-Jemal A, Bray F, Center MM, Ferlay J, Ward E,Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69-90. DOI: https://doi.org/10.3322/caac.20107

- Julie R. Ingelfinger, Anil K. Rustgi, and Hashem B. El‑Serag. Esophageal Carcinoma. N Engl J Med 2014; 371:2499-509. DOI: https://doi.org/10.1056/NEJMra1314530

- Peter C. Enzinger, and Robert J. Mayer. Esophageal Cancer. N Engl J Med 2003; 349:2241-52. DOI: https://doi.org/10.1056/NEJMra035010

- Denver Hendricks and M. Iqbal Parker. Esophageal Cancer in Africa. IUBMB Life 2002; 53: 263–268. DOI: https://doi.org/10.1080/15216540212643

- Duron V , Bii J , Mutai R , Ngetich J , Harrington D , Parker R , et al. Esophageal cancer awareness in Bomet district, Kenya. African Health Sciences 2013; 13(1): 122 – 128. DOI: https://doi.org/10.4314/ahs.v13i1.17

- Gholipour C, Shalchi RA, Abbasi M. A histopathological study of esophageal cancer on the western side of the Caspian littoral from 1994 to 2003. Dis Esophagus 2008; 21:322. DOI: https://doi.org/10.1111/j.1442-2050.2007.00776.x

-Gina D. Tran, Xiu-Di Sun, Christian C. Abnet, Jin-Hu Fan, Sanford M. Dawsey , Zhi-Wei Dong, et al. Prospective Study of Risk Factors for Esophageal and Gastric Cancers in the Linxian General Population Trial Cohort in China. Int. J. Cancer2005: 113, 456–463. DOI: https://doi.org/10.1002/ijc.20616

- Engel LS, Chow WH, Vaughan TL, Gammon MD, Risch HA, Stanford JL, et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 2003; 95:1404. DOI: https://doi.org/10.1093/jnci/djg047

- G.Manzoni, C. Pedrazzani, F. Pasini, E. Durante, M. Gabbani, A. Grandinetti, et al.Pattern of Recurrence after Surgery in Adenocarcinoma of the Gastro-Oesophageal Junction. Eur J Surg Oncol 2003; 29(6): 506-10. DOI: https://doi.org/10.1016/S0748-7983(03)00098-2

- Purushottam A. Giri, Kailash K. Singh, Deepak B. Phalke. Study of socio‑demographic determinants of esophageal cancer at a tertiary care teaching hospital of Western Maharashtra, India. South Asian Journal of Cancer 2014; 3 : 1.

- Pohl H, Wrobel K, Bojarski C, Voderholzer W, Sonnenberg A, Rosch T, et al. Risk factors in the development of esophageal adenocarcinoma. Am J Gastroenterol. 2013; 108(2):200–7 DOI: https://doi.org/10.1038/ajg.2012.387

- Sachin Wani, Jennifer Drahos, Michael B. Cook, Amit Rastogi, Ajay Bansal, Roy Yen, et al. Comparison of endoscopic therapies and surgical resection in patients with early esophageal cancer: a population-based study. Gastrointestinal Endoscopy 2014; 79: (2). DOI: https://doi.org/10.1016/j.gie.2013.08.002

- Karen Leffondre, Michal Abrahamowicz, Jack Siemiatycki, and Bernard Rachet. Modeling Smoking History: A Comparison of Different Approaches. Am J Epidemiol 2002; 156:813–823. DOI: https://doi.org/10.1093/aje/kwf122

- World Health Organization. BMI Classification; Global Database on BodyMassIndex.2006.Availablefrom:http://www.who.int/bmi/index.jsp?introPage=intro_3.html.[Accessed April, 2015].

- Bowman SA, Friday JE, Moshfegh A. MyPyramid Equivalents Database, 2.0 for USDA Survey Foods, 2003-2004 [Online] Food Surveys Research Group. Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville (2008). Available at: http://www.ars.usda.gov/ba/bhnrc/fsrg.

- Farhad Islami, Akram Pourshams, Dariush Nasrollahzadeh, Farin Kamangar, Saman Fahimi, Ramin Shakeri, et al. Tea drinking habits and esophageal cancer in a high risk area in northern Iran: population based case-control study. BMJ 2009; 338:929. DOI: https://doi.org/10.1136/bmj.b929

- Farhana Badar, Natasha Anwar, Shahid Mahmood. Geographical Variation in the Epidemiology of Esophageal Cancer in Pakistan. Asian Pacific J Cancer Prev 2005; 6:139-142.

- Jijo V.Cherian, Ramalingam Sivaraman, Arun K. Muthusamy, and Venkataraman Jayanthi. Carcinoma of the Esophagus in Tamil Nadu (South India):16-year Trends from a Tertiary Center. Gastrointestin Liver Dis 2007; 16 (3):245-249.

- Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010; 17(6):1471–4. DOI: https://doi.org/10.1245/s10434-010-0985-4

- M. Stahl, C. Mariette, K. Haustermans, A. Cervantes & D. Arnold. Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 2013; Volume 24 (Supplement 6): 51–56. DOI: https://doi.org/10.1093/annonc/mdt342

- Maria Aparecida, Coelho A. Henry, Mauro Masson Lerco, Priscila Watson Ribeiro, Maria Aparecida and Marchesan Rodrigues. Epidemiological features of esophageal cancer. Squamous cell carcinoma versus adenocarcinoma Acta Cirúrgica Brasileira 2014; 29 (1). DOI: https://doi.org/10.1590/S0102-86502014000600007

- Stigler S. Fisher, the 5% level. Chance 2008; 21(4):12. DOI: https://doi.org/10.1080/09332480.2008.10722926

- Tahir A. Hawramy, Faiq M. Ahmad Golpy. Carcinoma of the Esophagus in Sulaimany Province. Journal of Zankoy Sulaimai 2002 ;(5):27-37. DOI: https://doi.org/10.17656/jzs.10086

- Mohammad Ali Mashhadi, Kazem Nezam, Ali Reza Bakhshipour, Tahere Fajharian Ttorbati, Ali Reza Ansarimoghaddam .High Prevalence of Esophageal Cancer in South East of Iran. International Journal of Hematology Oncology and Stem Cell Research 2011; Vol. 5, No.4.

- John F. Gibbs, Ashwani Rajput, Krishdeep S. Chadha, Wade G. Douglas, Hank Hill, Chukwumere Nwogu, et al. The Changing Profile of Esophageal Cancer Presentation and Its Implication for Diagnosis. Journal of the National Medical Association 2007; 99, (6).

- Aledavood A, Anvari K , Sabouri G1. Esophageal Cancer in Northeast of Iran. Iran J Cancer Prev 2011; 3:125-129.

- Wu MT, Wu DC, Hsu HK, Kao HK, Lee JM. Constituents of areca chewing related to esophageal cancer risk in Taiwanese men. Dis Esophagus. 2004; 17:257–259. DOI: https://doi.org/10.1111/j.1442-2050.2004.00419.x

- Shad Salim Akhtar, Lolita Malig Reyes. CANCER INAL-QASSIM SAUDIARABIA: A retrospective study (1987-1995).Breast Cancer Researches in Saudi Arabia2011; 2 (1).

- A. Akhavan, A. Seifadini. Squamous cell carcinoma of hypopharynx in a patient with history of celiac disease. The Chinese-German Journal of Clinical Oncology2012; 11: (6), pp 367-368. DOI: https://doi.org/10.1007/s10330-011-0953-x

- Chen, T., Nines, R.G., Kresty, L.A., Peschke, S.M., Ding, Y. and Stoner, G. Chemo preventive effects of 1,4-PBIT (dihydrobromide), a selective inducible nitric oxide synthase inhibitor on N-nitroso methyl benzylamine (NMBA) - induced rat esophageal tumorigenesis . Proc. Frontiers in Cancer Prevention Res 2003; A136.

- Wang JM, Xu B, Rao JY, et al. Diet habits, alcohol drinking, tobACo smoking, green tea drinking, and the risk of esophageal squamous cell carcinoma in the Chinese population. Eur J Gastroenterol Hepatol . 2007; 19:171–176. DOI: https://doi.org/10.1097/MEG.0b013e32800ff77a

- Blot WJ, McLaughlin JK, Fraumeni JF. Esophageal cancer. In: Schottenfeld D, Fraumeni JF, eds. Cancer epidemiology and prevention. New York: Oxford University Press, 2006. DOI: https://doi.org/10.1093/acprof:oso/9780195149616.003.0036

-Putz A, Hartmann AA, Fontes PR, Alexandre CO, Silveira DA, Klug SJ, et al. TP53 mutation pattern of esophageal squamous cell carcinomas in a high risk area (southern Brazil): role of life style factors. Int J Cancer 2002; 98:99-105. DOI: https://doi.org/10.1002/ijc.10128

- Sepehr A, Taniere P, Martel-Planche G, Zia’ee AA, Rastgar-Jazii F,

Yazdanbod M, et al. Distinct pattern of TP53 mutations in Squamous cell carcinoma of the esophagus in Iran. Oncogene 2001; 20:7368-74. DOI: https://doi.org/10.1038/sj.onc.1204912

- Ames BN,Wakimoto P. Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer 2002; 2:694-704. DOI: https://doi.org/10.1038/nrc886

- Michels, K. B., Fuchs, C. S. & Giovannucci, E. Fiber intake and incidence of colorectal cancer among 76,947 women and 47,279 men. Cancer Epidemiol Biomarkers Prevention2005; 14:1619-1625. DOI: https://doi.org/10.1158/1055-9965.EPI-04-0544

- Soler, M., Bosetti, C. & Franceschi S. Fiber intake and the risk of oral, pharyngeal and esophageal cancer. International Journal of Cancer 2011; 91(3).283–28. DOI: https://doi.org/10.1002/1097-0215(200002)9999:9999<::AID-IJC1047>3.0.CO;2-I

Published

2019-06-21

How to Cite

1.
Ibrahim A, Lake R, Salih K, Mohammed M. EPIDEMIOLOGIC AND PATHOLOGIC CHARACTERISTICS OF PATIENTS WITH ESOPHAGEAL CARCINOMA AT KURDISTAN CENTER FOR GASTROENTEROLOGY AND HEPATOLOGY. JSMC [Internet]. 2019 Jun. 21 [cited 2024 May 28];9(2):125-34. Available from: https://jsmc.univsul.edu.iq/index.php/jsmc/article/view/jsmc-10198

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