• Snoor Jalal Mustafa Department of Anatomy, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Gulala Ibrahim Qader Department of Pharmacology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
  • Shler Akram Faqe Mahmood Department of Microbiology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.



Monosodiun glutamate (MSG), Rats, Testes, Seminiferous tubules, Ginger, Testosterone



Monosodium glutamate (MSG) is commonly used food additive and flavor enhancer and it causes tissue damage. Ginger (Zingiber officinale), a medicinal plant that gaining popularity for its variety of biological protection activities.


This study was carried out to find out the protective role of ginger in eliminating the toxic effect of MSG on testicular tissue and testosterone hormone in rats.

Materials and Methods

Twenty four adult male rats were divided, randomly, into 3 equal groups. The 1st group was designed as control, the 2nd administered MSG orally at dose 4mg/kg body weight for 14 days and the 3rd group treated with MSG in oral doses of 4 mg/kg body weight plus Ginger extract at dose 100 mg /kg body weight for 14 days.


The study showed that MSG has altered the microarchitecture of testicular tissues, reduced seminiferous tubule diameter and germinal epithelial thickness, and increased the interstitial spaces with reduction in Leydig cells and Testosterone hormone level. In addition Ginger extract has prevented the MSG effect. All the results were significant statistically.


Ginger has protective and improving role against the effects induced by MSG on the rat testicular tissue.


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