VITAMIN D DEFICIENCY AND ITS ASSOCIATION WITH HYPOTHYROIDISM

Taha Othman Mahwi a and Neveen Nawzad Mahmood b



Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq. 
b University of Sulaimani, Kurdistan Region, Iraq.

 
 
Submitted: 4/8/2019; Accepted: 29/10/2019; Published: 21/12/2019

ABSTRACT


Background 

Vitamin D has a major role in autoimmune diseases, the vitamin D receptor (VDR) is expressed in a variety of body tissues including thyrocytes, it’s suggested that there is a potential role of vitamin D in the development of Hashimoto’s thyroiditis and its progression to hypothyroidism. Vitamin D deficiency is a worldwide problem that has health consequences.


Objectives 

To evaluate the association of vitamin D deficiency in hypothyroid patients in Sulaimani Governorate.


Methods

In this study 200 participants were included; consisted of 100 diagnosed hypothyroid patients and 100 healthy controls; age range was matched. All subjects (n = 200) were evaluated for 25(OH) vitamin D. Thyroid autoantibody [anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG)] levels with thyroid-stimulating hormone (TSH) and free thyroxine (T4) were measured in group 1.


Results

Serum 25(OH) vitamin D level was significantly lower in hypothyroid patients (13.6 ± 11.4ng/ml) than in controls (24.1 ± 20.7ng/ml), (P < 0.001). 83% of hypothyroid cases were vitamin D deficient, which is significantly more than control 54% (P< 0.001). (100) hypothyroid cases were correlated to anti-TPO and anti-Tg; (83) case had vitamin D deficiency, (66) and (46) cases of vitamin D deficient group were anti-TPO, anti-Tg positive respectively (P-value =0.42, P-value =0.13). 


Conclusions

Our findings indicate that patients with hypothyroidism present with lower vitamin D levels than healthy controls; deficiency of vitamin D was linked to the presence of antithyroid antibodies.


KEYWORDS

Vitamin D deficiency, Hypothyroidism, Autoimmune disease.