HYPOLIPIDEMIC EFFICACY OF ZINGIBER OFFICINALE EXTRACT IN COMPARISON WITH FENOFIBRATE, ROSUVASTATIN AND EZETIMIBE IN HYPERLIPIDEMIC RATS  

Kawa F. Dizaye a and Hani H. Mohammed b 



a College of Medicine, Hawler Medical University.
Department of Pharmacology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq. 

 
Submitted: 25/3/2019; Accepted: 29/7/2019; Published: 21/9/2019

ABSTRACT


Background 

Zingiber officinale (Ginger) is the most common used herb worldwide due to its great medicinal and culinary properties. The medicinal properties come from its antihyperlipidemic, anti-inflammatory, antiemetic, antimicrobial, anticancer and carminative actions. 


Objectives 

The present study was designed to evaluate and compare the effectiveness of different doses of Ginger decoction with, rosuvastatin, fenofibrate and ezetimibe on lipid profile, liver function test and MDA level in hyperlipidemic rats.


Methods

Fifty-four rats were divided into two groups. The first group included 18 rats and have subdivided into three subgroups each having 6 rats. The first subgroup served as a control. The second and the third subgroup received (2 ml and 4 ml) of ginger extract (10% W/V) daily respectively. The second group included 30 hyperlipidemic rats and they were subsequently subdivided into six subgroups each of 6 rats. The first subgroup served as positive control. The second subgroups received single doses of ginger (10% W/V). The third, fourth and sixth subgroups received Rosuvastatin (15 mg /kg), Fenofibrate (30mg/kg) and Ezetimibe (1mg/kg) respectively. At the end of treatment period (six weeks), all of these groups were subjected to various biochemical analysis of blood


Results

After six weeks of therapy, ginger extract significantly reduced serum total cholesterol, TG and LDL-C of hyperlipidemic rats, while it significantly increased serum HDL in both normal and hyperlipidemic rats. Daily administration of fenofibrate for six weeks caused significant reduction in serum TG and LDL-C and significantly increased serum HDL of hyperlipidemic rats. Whereas using of rosuvastatin (15mg/kg) and ezetimibe (1mg/kg) for six weeks lead to significant reduction in serum total cholesterol, TG, LDL-C and significantly increase in serum HDL in hyperlipidemic rats. Dose of 2 ml ginger 10% (W/V) decoction significantly reduced MDA level in normal rats, Furthermore Ginger extract and the other antihyperlipidemic drugs significantly decreased serum MDA level of hyperlipidemic rats. After 6 weeks of daily ingestion of different doses ginger decoction, serum ALP was significantly increased in normal rats. However, liver function test of hyperlipidemic rats was not significantly affected by ginger decoction. In another hand, rosuvastatin caused a significant elevation in serum ALP, while ezetimibe significantly reduced AST of hyperlipidemic rats.


Conclusion

Zingiber officinale decoction was effective as the other antihyperlipidemic agents in improving lipid profile. Although ginger has an antioxidant effect, but prolonged administration may have a hazardous hepatic side effect.



KEYWORDS

Hyperlipidemia, Ginger, Rosuvastatin, Fenofibrate, Ezetimibe.