USE OF LIPID PROFILE AS MARKER OF SEVERITY IN PRE-ECLAMPSIA

Maryam Bakir Mahmood a



 Department of Obstetrics and Gynaecology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.  


Submitted: 25/3/2019; Accepted: 18/6/2019; Published: 21/6/2019

ABSTRACT


Background 

Pre-eclampsia is the major cause of maternal morbidity and mortality, preterm birth, perinatal death, and intrauterine growth restriction. The incidence of pre-eclampsia globally varies widely from 5-15 percentages. Studies result’s find correlation of essential hypertension with alteration of serum cholesterol, triglycerides and HDL-C, various studies claim that abnormal lipid synthesis leading to increase of thromboxane level and the decrease of prostaglandin levels.


Objectives 

To assess changes in lipid profile in pre-eclampsia and if these changes can be used as a marker of severity of the condition.


Patients and Methods

Case-control Study at Sulaimani Maternity Teaching Hospital from 01. Feb. 2017 to 01. Aug. 2017, it includes 100 pregnant women divided into three groups. Control group who remained normotensive during study period and case group who subdivided to two group including those cases who developed mild and sever pre-eclampsia during study period.


Results

There was significant rise in the serum TC, TG, LDL and VLDL and decrease in HDL in pre-eclamptic groups compared to normal healthy pregnant women. When we compare patient with sever pre-eclampsia with patient with mild pre-eclampsia we found that women with sever pre-eclampsia has significantly higher level of TG (334.9 ± 97.8vs 250.2 ± 31.5) and VLDL (66.4 ± 19.8vs45.4 ± 12.7 only.


Conclusion

Maternal dyslipidemia early in second trimester may be an indicator for development of future pre-eclampsia.



KEYWORDS

Pre-eclampsia serum cholesterol, Triglyceride, Low-density lipoprotein, High-density lipoprotein, Very low-density lipoprotein.