CORRELATION BETWEEN CHEMOKINE RECEPTOR (CXCR4) EXPRESSION AND CLINICOPATHOLOGICAL FACTORS IN PATIENTS WITH PROSTATE CANCER

Lusan Abdulhameed Arkawazi a



 Department of Pathology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

Submitted: 30/2/2019; Accepted: 18/6/2019; Published: 21/6/2019


ABSTRACT


Background 

Prostate cancer is the second leading cause of cancer-related deaths. Different studies with conatroversial outcomes tried to find a link between CXCR4 level and other clinicopathological characters. 


Objectives 

To analyze the correlation of CXCR4 with prostate-specific antigen, age of the patients and Gleason score.


Materials and Methods

This is a retrospective cross-sectional study using paraffin-embedded blocks of prostate cancer. For CXCR4 visualization, immunohistochemistry (IHC) based on staining method for demonstration of its level was used to score them according to the extent and the staining intensity of the nucleus as: 0 (no signals for tissue staining), 1 (when tissue extent and intensity for staining is weak), 2 (extent and intensity of tissue staining is moderate), and 3 (when tissue extent and intensity staining is strong).


Results

Age of the patients ranged from 58-88 years, with the P value of 0.874 between the age and IHC staining score. The prostate-specific antigen level ranged from 9-100, the result was non-significant P value of 0.938 between PSA level and IHC staining score. There was also no significant relation between the level of CXCR4 (IHC staining score) and the Gleason score P value of 0.206.


Conclusion

High CXCR4 expression couldn’t be related to the clinical parameters such as pretreatment PSA level, the age of the patients, and histopathological findings of prostate cancer using Gleason score.



KEYWORDS

Prostate cancer, CXCR4, Prostate specific antigen, Immunohistochemistry, Plasma membrane, Transurethral resection of prostate.