PREVALENCE OF HELICOBACTER PYLORI INFECTION USING FECAL ANTIGEN AND SEROLOGY AND ITS RELATION TO IRON DEFICIENCY ANEMIA

Khanda Abdullateef Anwar a



 Department of Microbiology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.



Submitted: 17/2/2019; Accepted: 3/5/2019; Published: 21/6/2019

ABSTRACT


Background 

Helicobacter pylori is an important pathogen, that colonize the mucus layer of epithelial mucus of the stomach in approximately 50% of humans worldwide and can be diagnosed by both invasive and noninvasive methods. 


Objectives 

to compare the diagnostic accuracy of noninvasive tests such as serology and stool antigen test in symptomatic patients and observing the relation of these tests to hematological parameter.


Materials and Methods

One hundred and fifteen blood and stool samples were taken from patients with dyspeptic symptoms from primary health care center of Shahid baxtyar clinic in Sulaimani (Iraq) in a period from June to December 2015, and analyzed for detection of Helicobacter pylori infection by different methods. 


Results

The most attending group that have Helicobacter pylori infection were adult female with age group 26-35 years. Different percentage was recorded for each diagnostic maethod, 76.52% for rapid test, 62.60% for stool Ag, 67.82% for IgM and 86.96 % was recorded for IgG ELISA test. Serum ferritn was assessed for all patients and it was observed that 78 (67.82%) showed low serum ferritin level that includes all cases of positive stool Antigen.


Conclusion

H. pylori can be detected by all non invasive methods with predominent of serodiagnostic test and most of positive cases had iron deficiency anemia with low serum ferritin level. 




KEYWORDS

Helicobacter pylori, Non invasive methods, ELISA test, Stool Ag.