COMPARISON OF THE EFFICACY OF CRYOTHERAPY, INTRALESIONAL SODIUM STIBOGLUCONATE AND 7% SODIUM CHLORIDE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS

Darsim M. Abdalla a, Shirwan H. Omer b and Abdullah M. Dawoud c



a Department of Medicine, College of Medicine, University of Sulaimani. 
b Department of Physiology, College of Medicine, University of Sulaimani. 
c Kirkuk Directory of Health, Ministry of Health, Iraq.


Submitted: 2/7/2018; Accepted: 11/11/2018; Published 21/12/2018
ABSTRACT


Background 

Cutaneous leishmaniasis is an endemic disease for which many therapies had been used, aiming to kill the parasite and induce cure with minimum scarring. Intralesional Sodium stibogluconate, cryosurgery and intralesional Sodium Chloride 7% solution were among these therapies.


Objectives 

To compare between intralesional Sodium stibogluconate, cryotherapy and intralesional Sodium Chloride 7% solution in treatment of cutaneous leishmaniasis regarding their efficacies and side effects. 


Patients and methods

This study involved 82 patients with cutaneous leishmaniasis. The entire subjects met certain inclusion and exclusion criteria. The patients were divided according to the type of treatment into three groups. In group (A) 28 patients were treated with Intralesional Sodium stibogluconate, group (B) Cryosurgery was used for treatment of 29 patients and in group (C) Intralesional Sodium Chloride 7% solution was used for treatment of the remaining 25 patients. We were followed all patients for 12 weeks after completion of the treatments 


Results

There were significant association between the following parametres, complete clearance of cutaneous leishmaniasis and the use of intralesional Sodium stibogluconate (p=0.02), lowest pain scores during treatment and the use of cryosurgery in group (p<0.001), and between decreased visits number of treatment and the use of intralesional Sodium Chloride 7% solution in group (C) (p=0.05).


Conclusion

Intralesional Sodium stibogluconate was the most effective treatment of cutaneous leishmaniasis followed by cryosurgery and Sodium Chloride 7% solution was the least effective one.



KEYWORDS

Cutaneous leishmaniasis, Stibogluconate, Cryosurgery and Sodium Chloride 7% solution.