ALLRED SCORE DIRECTLY ASSOCIATED TO BODY MASS INDEX IN KURDISH PREMENOPAUSAL WOMEN WITH BREAST CANCER


Hazha Abdullah Mohammed Ameen a


a Department of Medicine, College of Medicine, University of Sulaimani. 


Submitted: 2/3/2018; Accepted: 12/8/2018; Published 15/10/2018
ABSTRACT


Background 

Obesity has been documented as an important prognostic factor and increased mortality with each successive increase in body mass index (BMI). It is unclear whether these associations differ among breast cancer subtypes.


Objectives 

To know the association of the Allred score which has both predictive and prognostic value, with the body mass index in Kurdish Premenopausal women with breast cancer.


Patients and Methods

This study carried out at Hiwa hematology/oncology hospital of Sulaimani between June 2007 to December of 2015. Age, menopausal status, hormone receptor, Her-2 neu status height, weight, and body mass index were studied. Allred score by immunohistochemistry of all breast cancer patients was retrospectively analyzed.


Results

We conducted a population-based case-case study consisting of 519 women diagnosed with invasive breast cancer. Mean age of the studied group was 47.3±9.2 years. Mean menopausal age was 51±3 years; almost two-thirds of whom were premenopausal. Mean BMI of breast cancer patients was 30.1±5.6 kg/m2; 47% were obese. There was a strong association between high BMI and breast cancer in the age period of 40 to 49 years (p=0.03). The obese patient had a high tumor grade, ki67 and stage III disease. Strong expression of both Estrogen and progesterone receptors were observed in obese premenopausal patients.


Conclusion

Obese women usually presented with an increased risk of breast cancer in premenopausal women, advanced stage, and the majority of them had positive hormonal receptor status (ER/PR) Estrogen Receptor /Progesterone Receptor. Fortunately, obese linked to high Allred score with good response to hormonal therapy and better survival.



KEYWORDS

Breast Cancer, Body Mass Index, Obesity, Estrogen Receptor, Allred Score.