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jsmc-10119


COMPARING THE EFFECT OF MIDAZOLAM AND METOCLOPRAMIDE ON PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANESTHESIA  


Gona A. M. Ali a and Aree H. R. Hama b


 Department of Surgery, College of Medicine, University of Sulaimani.
b Directorate of Health, Sulaimani.

 

Submitted: 23/2/2017; Accepted: 1/8/2017


ABSTRACT

Background

Postoperative nausea and vomiting is one of the most frequent complications of general anesthesia. The overall incidence of postoperative nausea and vomiting is currently estimated to be around 20 to 30% and in certain high-risk patients; this incidence may reach 70% .

Aims

The aim of the study is to compare the antiemetic efficacy of midazolam or metoclopramide in laparoscopic surgery under general anesthesia.


Methods

In this study 120 patients (ASA I–II) whom underwnet laparoscopic cholecystectomy in Sulaimani Teaching Hospital were evaluated as double-blinded randomized study, patients were allocated randomly to one of three main groups: Group 1 (n= 40) received midazolam (0.03 mg/kg) i.v as a premedication, Group 2 (n= 40) received metoclopramide (10 mg) i.v as a premedication and Group 3 (n= 40) received standard premedication. Anesthesia was standardized for all patients, follow up done for them up to 24 hrs. Data were interpreted by Chi-square test and Pearson’s test, using Statistical Package of Social Sciences Software (SPSS).

Results

The incidence of postoperative nausea and vomiting was 20% with midazolam (P < 0.05), 35% with metoclopramide (P >0.05), and 57.5% with none of two drugs.

Conclusion

Midazolam is more effective than metoclopramide in preventing post-operative nausea and vomiting.

KEYWORDS

Post operative nausea and vomiting, Midazolam and Metoclopramide.