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jsmc-10101


STATUS OF CIRCULATING SERUM TRYPTASE IN HEALTHY OBESE AND COMORBIDLY OBESE CONDITIONS


Tebeen Jamal Nadir a, Zhian Salah Ramzi b, Ban Mousa Rashid cSaman Hussein Noori a, Taha Othman Mahwi d and Beston Faiek Nore a,e


a Department of Biochemsitry, College of Medicine, University of Sulaimani.
b Department of Family and Community Medicine, College of Medicine, University of Sulaimani.
c Department of Biochemsitry College of Pharmacy, University of Sulaimani.
d Department of Medicine, College of Medicine, University of Sulaimani.
e Dept. of Health, Kurdistan Institution for Strategic Studies and Scientific Research, Sulaimani, Kurdistan Region, Iraq.


Submitted: 3/9/2016; Accepted: 12/12/2016


ABSTRACT


Background

Serum Tryptase is one of most abundant protease secreted by mast cells and it account as indirect measure for a number of human abnormalities, such as mastocytosis, systemic anaphylaxis, obesity, allergy, asthma and various forms of cancer.

Objectives

In this study we focused on obese individuals and we investigated the relationships between total Serum Tryptase with age, gender, classes of obesity with/or without type 2 diabetes mellitus or dyslipidemia.

Methods

Estimation of serum tryptase, body mass index, lipid profile, and serum glucose were performed in population of 250 participants aged 12-80 years.

Results

Serum tryptase significantly increased with body mass index, with higher level of serum tryptase found among diabetic obese than healthy obese individuals. There was significantly increase serum tryptase with age, but no correlation was found between serum tryptase and gender, hemoglobin A1c, and fasting blood glucose.

Conclusion

Level of serum tryptase increases with age, being much more pronounced in adults older than > 16 years old than individuals < 16 years old regardless of their body mass index. Serum tryptase is significantly higher in serum’s of all obese participants compared to the healthy participants, regardless of the obesity-related complications; while the obesity related type 2 diabetes mellitus patients shows a significantly highest level of serum tryptase compared to all other groups.

KEYWORDS

Serum Tryptase, obesity, Type 2 diabetes mellitus, Dyslipidemia, Body mass index.