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jsmc-10093


PROTECTIVE ROLE OF GINGER ON TESTICULAR TISSUE AND TESTOSTERONE HORMONE OF MALE RATS EXPOSED TO MONO-SODIUM GLUTAMATE


Snoor Jalal Mustafa *, Gulala Ibrahim Qader** and Shler Akram Faqe Mahmood ***


*   Department of Anatomy, College of Medicine, University of Sulaimani.
**  Department of Pharmacology, College of Medicine, University of Sulaimani.
*** Department of Microbiology, College of Medicine, University of Sulaimani.


Submitted: 4/1/2016; Accepted: 12/6/2016Published: 1/12/2016


ABSTRACT


Background 

Monosodium glutamate (MSG) is commonly used food additive and flavor enhancer and it causes tissue damage. Ginger (Zingiber officinale), a medicinal plant that gaining popularity for its variety of biological protection activities.

Objectives

This study was carried out to find out the protective role of ginger in eliminating the toxic effect of MSG on testicular tissue and testosterone hormone in rats.

Materials and Methods

Twenty four adult male rats were divided, randomly, into 3 equal groups. The 1st group was designed as control, the 2nd administered MSG orally at dose 4mg/kg body weight for 14 days and the 3rd group treated with MSG in oral doses of 4 mg/kg body weight plus Ginger extract at dose 100 mg /kg body weight for 14 days.

Results

The study showed that MSG has altered the microarchitecture of testicular tissues, reduced seminiferous tubule diameter and germinal epithelial thickness, and increased the interstitial spaces with reduction in Leydig cells and Testosterone hormone level. In addition Ginger extract has prevented the MSG effect. All the results were significant statistically.

Conclusion

Ginger has protective and improving role against the effects induced by MSG on the rat testicular tissue.

KEYWORDS

Monosodiun glutamate (MSG), Rats, Testes, Seminiferous tubules, Ginger, Testosterone.

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