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Haitham Issa Al-Banna*, Zhian Salah Ramzi** and Hero Mohamad Jalal ***

*    Hawler Medical University/ Hawler College of Medicine-Community Medicine Department.
**  Department of Community Medicine, College of Medicine, University of Sulaimani.
*** Sulaimania Directorate of Health.

Submitted: 2/2/2016; Accepted: 1/6/2016Published: 1/12/2016



Diabetes mellitus is a of metabolic disorder of carbohydrate metabolism in which glucose is under-utilized producing hyperglycemia and changes in lipid profile.


To find out prevalence of dyslipidemia among type1 diabetic and relation of dyslipidemia with control of diabetes mellitus and its duration.

Patients and Methods
The study was done in a diabetic center from July to November 2013, in which 159 Type 1diabetic patients participate, during the interviews a questionnaire was filled including demographic characteristics in addition to laboratory investigation including fasting plasma glucose, glycosylated hemoglobin and lipid profile. SPSS was used to measure means; Chi-square and logistic regression were used when indicated to be significant at p-value ≤ 0.05.


One hundred fifty nine patients were involved in this study. Eighty three female, their age between 13-35 years, Glycosylated hemoglobin was <7% in 13(8.2%) of them and ≥7% in 146 (91.8%). Dyslipidemia present in 89.9% of our patients. Significant relationship between glycosylated hemoglobin with only low density lipoprotein (p= 0.03) and total cholesterol (p= 0.04). Also significant relation found in high triglyceride in male (p= 0.01) with low high density lipoprotein in female (p=0.03) and between duration of DM and only low density lipoprotein (p= 0.01). Significant association was found between all lipid profile except total cholesterol and high body mass index.


High percentage of dyslipidemia found in current study associated with poor control of diabetes mellitus and high body mass index. Obesity, gender, duration of diabetes. Diastolic blood pressure and occupation can be used to predict some parameters of lipid profile.


Diabetes Mellitus, Dyslipidemia, Glycosylated hemoglobin, Body mass index.


1.Vasudevan DM ,Srekumari S, Vaidyanathan K .Text Book of Biochemistry for Medical Students. 6th ed. New Delhi: Jaypee brothers; 2011.P.113-90.

2.Jameson JL. HARRISON’S Endocrinology. 2nd ed. New York: McGraw Hill ; 2010. P.267-70.

3.Manu Arora, Shyamal Koley, Sunil Gupta , Sandhu JS. A Study on Lipid Profile and Body Fat in Patients with Diabetes Mellitus. Anthropologist. 2007; 9(4): 295-8.

4.Malhotra A, Wolford JK.  The American Diabetes Association GENNID Study Group. Analysis of Quantitative Lipid Traits in the Genetics of NIDDM (GENNID) Study Diabetes 2005; 54:3007-14.

5.Ory DS, Schaffe JE. ApoA-1 in Diabetes: Damaged Goods. Diabetes 2010; 59:2358-9

6.Ren S, Lee H, Hu L, Lu L, Shen GX. Impact of Diabetes-Associated Lipoproteins on Generation of  Fibrinolytic Regulators from Vascular Endothelial Cells. Journal of Clinical Endocrinology and Metabolism. 2002; 87(1):286-91.

7.Spratt KA. Managing Diabetic Dyslipidemia:  Aggressive Approach. Journal of the American Osteopathic Association. 2009; 109:2-7.

8. Ministry of Planning and Development Cooperation; Central Organization for Statistics and Information Technology, Annual per capita income report in Iraq. 2012 June 21.

9. American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care   2013; 36(1):11-66 .

10.Frohlich J, Dobiášová M . Fractional esterification rate of cholesterol and ratio of triglycerides to HDL cholesterol are powerful predictors of positive findings on coronary angiography. Clinical Chemistry. 2008; 49: (11) 1873-80.

11.Rodrigues TC, Pecis M, Canani LH, Schreiner L, KramerCK, Biavatti K, et al. Characterization of patients with type 1 diabetes mellitus in southern Brazil: chronic   complications  and associated factors . Revista da Associacao Medica Brasileira Journal. 2010; 56(1): 67-73

12. Al-Naama LM ,  Ajlan SK , Mahmood MS . Evaluation of Lipid and Lipoprotein Profile in Patients with Insulin Dependent Diabetes Mellitus. Journal of the Bahrain Medical Society. 2009; 21(3):298-301 

13.Wadwa RP, Kinney GL, Maahs DM, Snell-Bergeon J, Hokanson JE, Garg SK, et al . Awareness and Treatment of Dyslipidemia in Young Adults with Type 1 Diabetes. Diabetes Care 2005; 28(5):1051-6.

14.Masram SW, Bimanpalli MV, Suresh G S. Study of Lipid Profile and Glycated Hemoglobin in Diabetes Mellitus. Indian Medical Gazette Journal. 2012; 146(7):257-65.

15.Idzior-Walus B, Mattock MB, Solnica B, Stevens L, Fuller JH; EURODIAB IDDM Complications Study Group. Factors associated with plasma lipids and lipoproteins in Type 1 diabetes mellitus: the EURODIAB IDDM Complications Study. Diabetic Medicine 2001; 18(10):786-96.

16.Ogbera AO, Fasanmade OA, Chinenye S, Akinlade A. Characterization of lipid parameters in diabetes mellitus – a Nigerian report. International Archives of Medicine. 2009; 2 (1):19. 

17.Uttra KM, Devrajani BR, Ali Shah SZ, Devrajani T, Thanwar Das T, Raza S, et al. Lipid Profile of Patients with Diabetes mellitus in Pakistan . World Applied Sciences Journal 2011; 12 (9): 1382-4.

18.Gylling H, Tuominen JA,  Koivisto VA, Miettinen TA. Cholesterol Metabolism in Type 1 Diabetes. Diabetes. 2004; 53: 2217-22.

19.Ferretti G, Bacchetti T, Busni D, Rabini RA, Curatola G. Protective effect of paraoxonase activity in high-density lipoproteins against erythrocyte membranes peroxidation: a comparison between healthy subjects and type 1 diabetic patients. Journal of Clinical Endocrinology and Metabolism. 2004 ; 89(6): 2957-62.

20.Petitti DB, Imperatore G, Palla SL, Daniels SR, Dolan LM, Kershnar AK, et al. Serum Lipids and Glucose Control. Archives of  Pediatrics and  Adolescent  Medicine Journal. 2007; 161:159-65.

21.Maahs DM. Association of glycaemia with lipids in adults with type 1 diabetes: modification by dyslipidemia medication. Diabetologia. 2010 ; 53(12): 2518-25

22.Perez A, Wagner AM, Carreras G, Gimenez G, Sanchez-Quesada JL, Rigla M, et al. Prevalence and Phenotypic Distribution of Dyslipidemia in Type 1 Diabetes Mellitus. Archives of  Internal Medicine Journal. 2000; 160: 2756-62.

23.Mayer-Davis EJ, Bo Ma, Lawson A, D’Agostino RB, Liese AD, Bell RA, et al . Cardiovascular Disease Risk Factors in Youth with Type 1 and Type 2 Diabetes: Implications of a Factor Analysis of Clustering. Metabolic Syndrome and  Related Disorder Journal. 2009; 7(2):89-95.

24. Mengesha AY. Lipid profile among diabetes patients in Gaborone, Botswana. South African Medical Journal . 2006; 96:147-8. 

25.Setoodeh A, Mostafavi F , Rabbani A , Hedayat T. Female Sex as a Risk Factor for Glycemic Control and Complications in Iranian Patients with Type 1 Diabetes Mellitus. Iranian Journal of Pediatric. 2011; 21(3):373-8. 

26.Hamad A, Qureshi HJ . Dyslipidemia in recently diagnosed young subjects of type1 diabetes mellitus with normal favorable BMI: a risk factor of macro vascular disease. Biomedical. 2008; 24:130-3.

27.AL-Janabi A M.  The influence of body mass index on glycosylated hemoglobin and lipid profile in diabetic patients. Kufa  Medical  Journal . 2010; 13(1):104-11.

28.Ladeia AM, Adan L, Couto-Silva AC, Hiltner A, Guimaraes AC. Lipid profile correlates with glycemic control in young patients with type1 diabetes mellitus.  Preventive  Cardiology. 2006 Spring ; 9(2): 82-8.