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jsmc-10040


ANTIMULLERIAN HORMONE SERUM CONCENTRATIONS IN NORMOOVULATORY AND ANOVULATORY WOMEN OF REPRODUCTIVE AGE


Ariana K Jawad * and Mahabad S Ali **


* Maternity Teaching Hospital, Erbil.


Submitted: 24/12/2012; Accepted: 21/7/2013Published 1/12/2013
ABSTRACT


Background

Anti-Mullerian hormone (AMH), produced by growing pre-antral and early antral ovarian follicles, has been shown to be a useful marker for ovarian ageing. Serum AMH concentrations are elevated during reproductive life in anovulatory women, especially in those patients exhibiting polycystic ovaries (PCO) and have been implicated in the pathogenesis of polycystic ovary syndrome (PCOS).

Objectives

The aim of our study is to compare the AMH concentrations in anovulatory women with normoovulatory women of similar age.

Patients and Methods

The study included 70 anovulatory normogonadotrophic women (50 cases with PCOS and 20 cases with Non-PCOS anovulatory women) and 30 cases control group (normal ovulatory women). PCOS patients was diagnosed according to the Rotterdam definition, Serum AMH was measured with a second-generation immunoassay in both groups.

Results

Mean AMH level in anovulatory group was 2.22 ng/ml (0.6-4.10) and for control group was 6.11 (0.10- 19.00), there was significant difference in AMH, LH and testosterone level between patients and control group, difference also significant in AMH level between PCOS and non-PCOS subgroup. There was negative correlation between age of the women and AMH level both in control and patient group.

Conclusion

Serum AMH concentrations are elevated in anovulatory, especially in those patients exhibiting PCOS.

KEYWORDS

AMH, Anovulatory, Ovulatory, Reproductive age.

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