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jsmc-10032


BENZHEXOL (ARTANE) ABUSE IN AN IRAQI FEDERAL PRISON IN KURDISTAN REGION


Nazar M Mohammad Amin * and Danial Saadi Hamid **


*  Raparin Pediatric Teaching Hospital, Erbi, Kurdistan Region, Iraq.
** Hawler Medical University and Consultant Neonatologist, Raparin Pediatric Teaching Hospital.


Submitted: 21/12/2012; Accepted: 7/3/2013Published 1/6/2013


ABSTRACT


Background

Artane is an anticholinergic drug which is prescribed by doctors to patients throughout the world. It is also abused by psychotic patients and nonpsychotic young people. This problem was highlighted in the Middle East recently. Prisons in Iraq were among the places where the abuse was obvious.

Objectives

This study was carried out to determine the prevalence of Artane abuse among the prison inmates, finding the demographic data about Artane abuser inmates and to find sources of Artane supplies to prison inmates

Methods

Among inmates of one of the prisons in Kurdistan Region, 508 were interviewed for addiction on various substances (in the period from 15th of January 2007 to 1st of October 2007).

Results

The research found 146 (28.7%) of the 508 Interviewed to be dependent on substances. Artane was found to be the main drug that was abused by inmates. They were mostly young, single and were addicted on other substances with Artane.

Conclusion

Artane abuse is a problem in Iraq and Kurdistan Region that needs to be addressed by the medical, legal and social authorities in the region. Prisons are among the places that need to be looked at for this abuse.

KEYWORDS

Artane, Trihexyphenydil, Abuse, Prisoners, Benzhexol.

References 

1. Marriott P G. Dependence on antiparkinsonian drugs. Br Med J. 1976; Vol. 17, pp 152. 

2. Hariatmadari, M. E. 1975. Letter: Orphenadrine dependence. Br Med J, 3, 486.

3. Rubinstein JS. Abuse of antiparkinsonism drugs. Feigning of extrapyramidal symptoms to obtain trihexyphenidyl. JAMA : the journal of the American Medical Association. 1978;239 (22):2365-6. 

4. Stephens, D. A. Psychotoxic effects of benzhexol HCL. British Journal Psychiatry, (1967), 113, 213-18

5. Harrison G. The Abuse of Anticholinergic Drugs in Adolescents. British Journal of Psychiatry, 1980, 137: 495.

6. Woody GE, O'Brien CP. Anticholinergic toxic psychosis in drug abusers treated with benztropine. Comprehensive psychiatry. 1974;15 (5):439-42. 

7. Kaminer Y, Munitz H, Wijsenbeek H. Trihexyphenidyl (Artane) abuse: euphoriant and anxiolytic. The British journal of psychiatry : the journal of mental science. 1982;140:473-4 

8. Crawshaw JA, Mullen PE. A study of benzhexol abuse. The British journal of psychiatry: the journal of mental science. 1984;145:300-3.

9. Qureshi NA. Trihexyphenidyl (artane) abuse among Saudi psychiatric patients. Annals of Saudi medicine. 1992;12(4):391-4. 

10. Qureshi NA, Al Amri AH, Abdelgadir MH, El-Haraka EA. Trihexyphenidyl (Artane) dependence: A controlled investigation between users and abusers. Annals of Saudi medicine. 1997;17(2):185-90. 

11. Nappo SA, de Oliveira LG, Sanchez Z, Carlini Ede A. Trihexyphenidyl (Artane): a Brazilian study of its abuse. Substance use & misuse. 2005;40(4):473-82.

12. Younis A.A. & Moselhy H.F. Benzhexol-dependence resulting from self-medication for intermittent explosive disorder. International Journal of Psychiatry in Clinical Practice, 2009: 13 (1): 11-15

13. Salzmann M M. Benzhexol (artane) abuse BJP. 1982, 141:318-319.

14. Deutsch A, Eyma J. Massive ingestion of trihexyphenidyl. The American journal of psychiatry. 1992;149(4):574-5. 

15. Aqrawi R, Humphreys K. Responding to rising substance misuse in Iraq. Substance use & misuse. 2009;44(12):1744-8

16. Frauger E, Thirion X, Chanut C, Natali F, Debruyne D, Saillard C, et al. [Misuse of trihexyphenidyl (Artane, Parkinane): recent trends]. Therapie. 2003;58 (6):541-7.

17. El-Haj B, Al-Amri A, Ali HS. Target urinary analytes for the gas chromatographic- mass spectrometric detection of procyclidine and benzhexol in drug abuse cases. Journal of analytical toxicology. 2011;35(2):92-8.

18. Hadidi KA. Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden. Leg Med (Tokyo). 2004;6(4):233-41.

19. Hiller W, Zaudig M, Mombour W, Bronisch T. Routine psychiatric examinations guided by ICD-10 diagnostic checklists (International Diagnostic Checklists). European archives of psychiatry and clinical neuroscience. 1993;242(4):218-23.

20. Daniel S. Hamid.  Substance Dependence as a cause of Offensive Behavioure. A thesis submitted the Iraqi Board For Medical Specializations. 2007