USE OF PROPOFOL AS INTUBATION AID FOR CHILDREN ANESTHETIZED WITH SEVOFLURANE

Sami Waseem Sadeq a, Amanj A. Marouf b and Amir Murad Khudadad b 



Sulaimani Surgical Teaching Hospital, Kurdistan Region, Iraq
b College of Medicine, University of Sulaimani, Kurdistan Region, Iraq. 
 

Submitted: 6/10/2019; Accepted: 13/9/2020; Published: 21/9/2020

ABSTRACT


Background 

Use of muscle relaxants for tracheal intubation in pediatric patients been associated with significant side effects and complications during general anesthesia. Many anesthetic drug combinations have been used to facilitate intubation without the use of relaxants.


Objectives 

To compare the efficacy of three different doses of Propofol to obtain optimum intubating conditions.


Patients and Methods

One hundred and four pediatric patients enrolled in our study after ethical committee approval and written parental consent. Patients were belonging to the American Society of Anesthesiologist physical status classes (I and II), aged from 18 months to 5 years, and were scheduled for tonsillectomy and/or adenoidectomy. Patients were pre-medicated with midazolam 0.2 mg/kg and ketamine 3 mg/kg 15-30 minutes before induction orally. Patients were randomly divided into 4 groups: Group I (control group) did not receive Propofol, while Group II, Group III, and Group IV received (1, 2 and 3 mg/kg of intravenous Propofol respectively). Cough, movement of the limb, tachycardia and smooth intubation condition had been recorded during intubation.


Results

Cough, movement of the limbs, tachycardia were mostly reported among the control group (100%, 74%, 43%) respectively. While smooth intubation condition was mostly among the group IV. 1mg/kg Propofol abolished cough response. 2mg/kg Propofol abolished movement of the limbs. 3 mg/kg Propofol was superior to 2 mg/kg Propofol in decreasing tachycardia response and smooth intubation condition.


Conclusion

Propofol in a dose of 3 mg/Kg I.V. is an excellent adjuvant drug for smooth intubation in children anesthetized with Sevoflurane.



KEYWORDS

Sevoflurane, Propofol, Tracheal Intubation, Pediatric Anesthesia.