ASSOCIATION BETWEEN SERUM TRIGLYCERIDE LEVEL AND CHRONIC KIDNEY DISEASE IN TYPE 2 DIABETES MELLITUS 

Taha O. Mahwy a, Karokh Fazil Hamahussien b, and Delman Al-Attar c



a Department of Medicine, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq. 
b Kurdistan Board Candidate of Internal Medicine/ Kurdistan Region/ Iraq. 
c Faruk Medical City, Kurdistan Region, Iraq. 



Submitted: 16/5/2019; Accepted: 17/2/2020; Published: 21/3/2020

ABSTRACT


Background 

Diabetes mellitus type 2 is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and a relative lack of insulin. Diabetic kidney disease which is known as diabetic nephropathy is the chronic loss of kidney function occurring in those with diabetes mellitus and is the single strongest predictor of mortality in patients with diabetes. However, in spite of the achievement of recommended targets for blood glucose and blood pressure, the residual risk for diabetic nephropathy remains high among patients with type 2 diabetes. Hypertriglyceridemia may be one of the factors responsible for this high residual risk. Recent studies demonstrated that intra-renal accumulation of lipids may contribute to glomerular injury.


Objectives 

This study aimed to find an association between hypertriglyceridemia and chronic kidney disease in type 2 diabetes mellitus patients.


Patients and Methods

In this cross-sectional study 241 patients evaluated with documented type 2 diabetes mellitus to find any relation between hypertriglyceridemia and chronic kidney disease in type 2 diabetes mellitus. Data collected from 300 patients with type 2 diabetes mellitus, 161 males and 139 females. Of these 59 cases were excluded, 35 males and 24s female patients because of incomplete data was available, with mean age was 54.24 years. laboratory test for measuring fasting (total cholesterol, HDL, LDL, triglyceride, urinary albumin, and urinary creatinine) done using COBAS INTEGRA 400 PLUS (Roche), then ACR measured two samples was obtained.


Results

In our study 139 patients had high serum triglyceride level, the other 102 patients had normal serum triglyceride level. 154 patients had normal urine ACR, (n=77, 50.0%) had high triglyceride level, (n=77, 50.0%) had normal triglyceride level, 57 patients had microalbuminuria, (n=42, 73.7%) had high triglyceride level, (n=15, 26.3%) had normal triglyceride level, 30 patients had macroalbuminuria, (n=20, 66.7%) had high triglyceride level , (n=10, 33.3%) had normal triglyceride level, p-value was significant, (p<0.005) 


Conclusion

In the current study we found that hypertriglyceridemia is an independent risk factor for CKD. Furthermore, hypertension, hypercholesterolemia, high HbA1c and duration of diabetes were also identified as risk factors for CKD.



KEYWORDS

Hypertriglyceridemia, Chronic kidney disease, Diabetes mellitus type 2.